Genetic variants linked to education predict longevity
Marioni RE; Ritchie SJ; Joshi PK; Hagenaars SP; Okbay A; Fischer K; Adams MJ; Hill WD; Davies G; Nagy R; Amador C; Läll K; Metspalu A; Liewald DC; Campbell A; Wilson JF; Hayward C; Esko T; Porteous DJ; Gale CR; Deary IJ; Okbay A; Beauchamp JP; Fontana MA; Lee JJ; Pers TH; Rietveld CA; Turley P; Chen GB; Emilsson V; Meddens SF; Oskarsson S; Pickrell JK; Thom K; Timshel P; de Vlaming R; Abdellaoui A; Ahluwalia TS; Bacelis J; Baumbach C; Bjornsdottir G; Brandsma JH; Concas MP; Derringer J; Furlotte NA; Galesloot TE; Girotto G; Gupta R; Hall LM; Harris SE; Hofer E; Horikoshi M; Huffman JE; Kaasik K; Kalafati IP; Karlsson R; Kong A; Lahti J; van der Lee SJ; de Leeuw C; Lind PA; Lindgren KO; Liu T; Mangino M; Marten J; Mihailov E; Miller MB; van der Most PJ; Oldmeadow C; Payton A; Pervjakova N; Peyrot WJ; Qian Y; Raitakari O; Rueedi R; Salvi E; Schmidt B; Schraut KE; Shi J; Smith AV; Poot RA; St Pourcain B; Teumer A; Thorleifsson G; Verweij N; Vuckovic D; Wellmann J; Westra HJ; Yang J; Zhao W; Zhu Z; Alizadeh BZ; Amin N; Bakshi A; Baumeister SE; Biino G; Bønnelykke K; Boyle PA; Campbell H; Cappuccio FP; Davies G; De Neve JE; Deloukas P; Demuth I; Ding J; Eibich P; Eisele L; Eklund N; Evans DM; Faul JD; Feitosa MF; Forstner AJ; Gandin I; Gunnarsson B; Halldórsson BV; Harris TB; Heath AC; Hocking LJ; Holliday EG; Homuth G; Horan MA; Hottenga JJ; de Jager PL; Joshi PK; Jugessur A; Kaakinen MA; Kähönen M; Kanoni S; Keltigangas-Järvinen L; Kiemeney LA; Kolcic I; Koskinen S; Kraja AT; Kroh M; Kutalik Z; Latvala A; Launer LJ; Lebreton MP; Levinson DF; Lichtenstein P; Lichtner P; Liewald DC; Loukola A; Madden PA; Mägi R; Mäki-Opas T; Marioni RE; Marques-Vidal P; Meddens GA; McMahon G; Meisinger C; Meitinger T; Milaneschi Y; Milani L; Montgomery GW; Myhre R; Nelson CP; Nyholt DR; Ollier WE; Palotie A; Paternoster L; Pedersen NL; Petrovic KE; Porteous DJ; Räikkönen K; Ring SM; Robino A; Rostapshova O; Rudan I; Rustichini A; Salomaa V; Sanders AR; Sarin AP; Schmidt H; Scott RJ; Smith BH; Smith JA; Staessen JA; Steinhagen-Thiessen E; Strauch K; Terracciano A; Tobin MD; Ulivi S; Vaccargiu S; Quaye L; van Rooij FJ; Venturini C; Vinkhuyzen AA; Völker U; Völzke H; Vonk JM; Vozzi D; Waage J; Ware EB; Willemsen G; Attia JR; Bennett DA; Berger K; Bertram L; Bisgaard H; Boomsma DI; Borecki IB; Bultmann U; Chabris CF; Cucca F; Cusi D; Deary IJ; Dedoussis GV; van Duijn CM; Eriksson JG; Franke B; Franke L; Gasparini P; Gejman PV; Gieger C; Grabe HJ; Gratten J; Groenen PJ; Gudnason V; van der Harst P; Hayward C; Hinds DA; Hoffmann W; Hypponen E; Iacono WG; Jacobsson B; Järvelin MR; Jöckel KH; Kaprio J; Kardia SL; Lehtimäki T; Lehrer SF; Magnusson PK; Martin NG; McGue M; Metspalu A; Pendleton N; Penninx BW; Perola M; Pirastu N; Pirastu M; Polasek O; Posthuma D; Power C; Province MA; Samani NJ; Schlessinger D; Schmidt R; Sørensen TI; Spector TD; Stefansson K; Thorsteinsdottir U; Thurik AR; Timpson NJ; Tiemeier H; Tung JY; Uitterlinden AG; Vitart V; Vollenweider P; Weir DR; Wilson JF; Wright AF; Conley DC; Krueger RF; Smith GD; Hofman A; Laibson DI; Medland SE; Meyer MN; Yang J; Johannesson M; Visscher PM; Esko T; Koellinger PD; Cesarini D; Benjamin DJ
https://urn.fi/URN:NBN:fi-fe2021042716231
Tiivistelmä
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
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