Genetic variants linked to education predict longevity
Timshel P; Polasek O; Homuth G; Poot RA; Eibich P; Huffman JE; Paternoster L; van der Lee SJ; Schmidt B; Harris SE; Gupta R; Halldórsson BV; Benjamin DJ; de Leeuw C; Sarin AP; Pers TH; Kolcic I; Weir DR; Pickrell JK; Salvi E; St Pourcain B; Davies G; Liu T; Mangino M; Lahti J; Bultmann U; Bjornsdottir G; Yang J; Milaneschi Y; Borecki IB; Conley DC; Gasparini P; Esko T; Marten J; Kardia SL; Eklund N; Cusi D; Province MA; Pirastu M; Hall LM; Amador C; McMahon G; Lehtimäki T; Sanders AR; Cucca F; Rudan I; Jöckel KH; van Duijn CM; Schlessinger D; Derringer J; Salomaa V; Schraut KE; Milani L; Raitakari O; Kanoni S; Järvelin MR; Pirastu N; Joshi PK; Verweij N; Hofman A; Schmidt H; Deloukas P; Kalafati IP; Ritchie SJ; Gratten J; Palotie A; Baumbach C; van der Most PJ; Hagenaars SP; Hofer E; Payton A; Franke B; Smith BH; Thom K; Völzke H; Campbell H; Ware EB; Martin NG; Medland SE; Evans DM; Smith JA; Johannesson M; Boyle PA; Laibson DI; Tung JY; Oldmeadow C; Vozzi D; Bennett DA; Mihailov E; Attia JR; Loukola A; McGue M; Grabe HJ; Penninx BW; Horikoshi M; Bønnelykke K; Steinhagen-Thiessen E; Hayward C; Lichtenstein P; Rueedi R; Ulivi S; Girotto G; Timpson NJ; Kaakinen MA; Brandsma JH; Kutalik Z; Meyer MN; Nagy R; Smith AV; Meitinger T; Meisinger C; Bacelis J; Völker U; Okbay A; Nyholt DR; Qian Y; Heath AC; Vaccargiu S; Gale CR; Emilsson V; Spector TD; Rostapshova O; Schmidt R; Posthuma D; Franke L; Hoffmann W; Launer LJ; Wilson JF; Fischer K; Pedersen NL; Mägi R; Kaasik K; Teumer A; Lee JJ; Keltigangas-Järvinen L; Visscher PM; Horan MA; Adams MJ; Hypponen E; Lindgren KO; Cesarini D; Bakshi A; Strauch K; Lehrer SF; Tiemeier H; Staessen JA; Stefansson K; Cappuccio FP; Läll K; Petrovic KE; Terracciano A; Metspalu A; Gejman PV; Galesloot TE; Demuth I; Smith GD; Furlotte NA; Gandin I; Alizadeh BZ; Vollenweider P; Shi J; Hottenga JJ; Hill WD; Lebreton MP; Myhre R; Kroh M; Eisele L; Peyrot WJ; Oskarsson S; Iacono WG; Nelson CP; Kong A; Concas MP; Thorleifsson G; Campbell A; Dedoussis GV; Vitart V; Wellmann J; Ahluwalia TS; Lichtner P; Gudnason V; Vonk JM; Quaye L; Perola M; Thurik AR; Abdellaoui A; Robino A; Fontana MA; Sørensen TI; van Rooij FJ; Beauchamp JP; Kähönen M; Montgomery GW; Feitosa MF; Lind PA; Liewald DC; Bertram L; Westra HJ; Koskinen S; Willemsen G; Madden PA; Harris TB; De Neve JE; Vuckovic D; Porteous DJ; Miller MB; Zhu Z; Chen GB; Samani NJ; Uitterlinden AG; Gieger C; Jugessur A; Waage J; Meddens GA; Marioni RE; Biino G; Groenen PJ; Scott RJ; Eriksson JG; Ding J; de Vlaming R; Kraja AT; Kiemeney LA; Holliday EG; Pervjakova N; Pendleton N; Ring SM; Kaprio J; Amin N; Meddens SF; Rietveld CA; Berger K; Forstner AJ; Krueger RF; Deary IJ; Ollier WE; Turley P; Latvala A; Bisgaard H; Thorsteinsdottir U; van der Harst P; de Jager PL; Marques-Vidal P; Power C; Faul JD; Karlsson R; Vinkhuyzen AA; Hocking LJ; Chabris CF; Magnusson PK; Venturini C; Rustichini A; Koellinger PD; Levinson DF; Gunnarsson B; Zhao W; Wright AF; Mäki-Opas T; Jacobsson B; Baumeister SE; Räikkönen K; Tobin MD; Hinds DA; Boomsma DI
https://urn.fi/URN:NBN:fi-fe2021042716231
Tiivistelmä
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
Kokoelmat
- Rinnakkaistallenteet [19207]