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Genetic variants linked to education predict longevity

Timshel P; Polasek O; Homuth G; Poot RA; Eibich P; Huffman JE; Paternoster L; van der Lee SJ; Schmidt B; Harris SE; Gupta R; Halldórsson BV; Benjamin DJ; de Leeuw C; Sarin AP; Pers TH; Kolcic I; Weir DR; Pickrell JK; Salvi E; St Pourcain B; Davies G; Liu T; Mangino M; Lahti J; Bultmann U; Bjornsdottir G; Yang J; Milaneschi Y; Borecki IB; Conley DC; Gasparini P; Esko T; Marten J; Kardia SL; Eklund N; Cusi D; Province MA; Pirastu M; Hall LM; Amador C; McMahon G; Lehtimäki T; Sanders AR; Cucca F; Rudan I; Jöckel KH; van Duijn CM; Schlessinger D; Derringer J; Salomaa V; Schraut KE; Milani L; Raitakari O; Kanoni S; Järvelin MR; Pirastu N; Joshi PK; Verweij N; Hofman A; Schmidt H; Deloukas P; Kalafati IP; Ritchie SJ; Gratten J; Palotie A; Baumbach C; van der Most PJ; Hagenaars SP; Hofer E; Payton A; Franke B; Smith BH; Thom K; Völzke H; Campbell H; Ware EB; Martin NG; Medland SE; Evans DM; Smith JA; Johannesson M; Boyle PA; Laibson DI; Tung JY; Oldmeadow C; Vozzi D; Bennett DA; Mihailov E; Attia JR; Loukola A; McGue M; Grabe HJ; Penninx BW; Horikoshi M; Bønnelykke K; Steinhagen-Thiessen E; Hayward C; Lichtenstein P; Rueedi R; Ulivi S; Girotto G; Timpson NJ; Kaakinen MA; Brandsma JH; Kutalik Z; Meyer MN; Nagy R; Smith AV; Meitinger T; Meisinger C; Bacelis J; Völker U; Okbay A; Nyholt DR; Qian Y; Heath AC; Vaccargiu S; Gale CR; Emilsson V; Spector TD; Rostapshova O; Schmidt R; Posthuma D; Franke L; Hoffmann W; Launer LJ; Wilson JF; Fischer K; Pedersen NL; Mägi R; Kaasik K; Teumer A; Lee JJ; Keltigangas-Järvinen L; Visscher PM; Horan MA; Adams MJ; Hypponen E; Lindgren KO; Cesarini D; Bakshi A; Strauch K; Lehrer SF; Tiemeier H; Staessen JA; Stefansson K; Cappuccio FP; Läll K; Petrovic KE; Terracciano A; Metspalu A; Gejman PV; Galesloot TE; Demuth I; Smith GD; Furlotte NA; Gandin I; Alizadeh BZ; Vollenweider P; Shi J; Hottenga JJ; Hill WD; Lebreton MP; Myhre R; Kroh M; Eisele L; Peyrot WJ; Oskarsson S; Iacono WG; Nelson CP; Kong A; Concas MP; Thorleifsson G; Campbell A; Dedoussis GV; Vitart V; Wellmann J; Ahluwalia TS; Lichtner P; Gudnason V; Vonk JM; Quaye L; Perola M; Thurik AR; Abdellaoui A; Robino A; Fontana MA; Sørensen TI; van Rooij FJ; Beauchamp JP; Kähönen M; Montgomery GW; Feitosa MF; Lind PA; Liewald DC; Bertram L; Westra HJ; Koskinen S; Willemsen G; Madden PA; Harris TB; De Neve JE; Vuckovic D; Porteous DJ; Miller MB; Zhu Z; Chen GB; Samani NJ; Uitterlinden AG; Gieger C; Jugessur A; Waage J; Meddens GA; Marioni RE; Biino G; Groenen PJ; Scott RJ; Eriksson JG; Ding J; de Vlaming R; Kraja AT; Kiemeney LA; Holliday EG; Pervjakova N; Pendleton N; Ring SM; Kaprio J; Amin N; Meddens SF; Rietveld CA; Berger K; Forstner AJ; Krueger RF; Deary IJ; Ollier WE; Turley P; Latvala A; Bisgaard H; Thorsteinsdottir U; van der Harst P; de Jager PL; Marques-Vidal P; Power C; Faul JD; Karlsson R; Vinkhuyzen AA; Hocking LJ; Chabris CF; Magnusson PK; Venturini C; Rustichini A; Koellinger PD; Levinson DF; Gunnarsson B; Zhao W; Wright AF; Mäki-Opas T; Jacobsson B; Baumeister SE; Räikkönen K; Tobin MD; Hinds DA; Boomsma DI

Genetic variants linked to education predict longevity

Timshel P
Polasek O
Homuth G
Poot RA
Eibich P
Huffman JE
Paternoster L
van der Lee SJ
Schmidt B
Harris SE
Gupta R
Halldórsson BV
Benjamin DJ
de Leeuw C
Sarin AP
Pers TH
Kolcic I
Weir DR
Pickrell JK
Salvi E
St Pourcain B
Davies G
Liu T
Mangino M
Lahti J
Bultmann U
Bjornsdottir G
Yang J
Milaneschi Y
Borecki IB
Conley DC
Gasparini P
Esko T
Marten J
Kardia SL
Eklund N
Cusi D
Province MA
Pirastu M
Hall LM
Amador C
McMahon G
Lehtimäki T
Sanders AR
Cucca F
Rudan I
Jöckel KH
van Duijn CM
Schlessinger D
Derringer J
Salomaa V
Schraut KE
Milani L
Raitakari O
Kanoni S
Järvelin MR
Pirastu N
Joshi PK
Verweij N
Hofman A
Schmidt H
Deloukas P
Kalafati IP
Ritchie SJ
Gratten J
Palotie A
Baumbach C
van der Most PJ
Hagenaars SP
Hofer E
Payton A
Franke B
Smith BH
Thom K
Völzke H
Campbell H
Ware EB
Martin NG
Medland SE
Evans DM
Smith JA
Johannesson M
Boyle PA
Laibson DI
Tung JY
Oldmeadow C
Vozzi D
Bennett DA
Mihailov E
Attia JR
Loukola A
McGue M
Grabe HJ
Penninx BW
Horikoshi M
Bønnelykke K
Steinhagen-Thiessen E
Hayward C
Lichtenstein P
Rueedi R
Ulivi S
Girotto G
Timpson NJ
Kaakinen MA
Brandsma JH
Kutalik Z
Meyer MN
Nagy R
Smith AV
Meitinger T
Meisinger C
Bacelis J
Völker U
Okbay A
Nyholt DR
Qian Y
Heath AC
Vaccargiu S
Gale CR
Emilsson V
Spector TD
Rostapshova O
Schmidt R
Posthuma D
Franke L
Hoffmann W
Launer LJ
Wilson JF
Fischer K
Pedersen NL
Mägi R
Kaasik K
Teumer A
Lee JJ
Keltigangas-Järvinen L
Visscher PM
Horan MA
Adams MJ
Hypponen E
Lindgren KO
Cesarini D
Bakshi A
Strauch K
Lehrer SF
Tiemeier H
Staessen JA
Stefansson K
Cappuccio FP
Läll K
Petrovic KE
Terracciano A
Metspalu A
Gejman PV
Galesloot TE
Demuth I
Smith GD
Furlotte NA
Gandin I
Alizadeh BZ
Vollenweider P
Shi J
Hottenga JJ
Hill WD
Lebreton MP
Myhre R
Kroh M
Eisele L
Peyrot WJ
Oskarsson S
Iacono WG
Nelson CP
Kong A
Concas MP
Thorleifsson G
Campbell A
Dedoussis GV
Vitart V
Wellmann J
Ahluwalia TS
Lichtner P
Gudnason V
Vonk JM
Quaye L
Perola M
Thurik AR
Abdellaoui A
Robino A
Fontana MA
Sørensen TI
van Rooij FJ
Beauchamp JP
Kähönen M
Montgomery GW
Feitosa MF
Lind PA
Liewald DC
Bertram L
Westra HJ
Koskinen S
Willemsen G
Madden PA
Harris TB
De Neve JE
Vuckovic D
Porteous DJ
Miller MB
Zhu Z
Chen GB
Samani NJ
Uitterlinden AG
Gieger C
Jugessur A
Waage J
Meddens GA
Marioni RE
Biino G
Groenen PJ
Scott RJ
Eriksson JG
Ding J
de Vlaming R
Kraja AT
Kiemeney LA
Holliday EG
Pervjakova N
Pendleton N
Ring SM
Kaprio J
Amin N
Meddens SF
Rietveld CA
Berger K
Forstner AJ
Krueger RF
Deary IJ
Ollier WE
Turley P
Latvala A
Bisgaard H
Thorsteinsdottir U
van der Harst P
de Jager PL
Marques-Vidal P
Power C
Faul JD
Karlsson R
Vinkhuyzen AA
Hocking LJ
Chabris CF
Magnusson PK
Venturini C
Rustichini A
Koellinger PD
Levinson DF
Gunnarsson B
Zhao W
Wright AF
Mäki-Opas T
Jacobsson B
Baumeister SE
Räikkönen K
Tobin MD
Hinds DA
Boomsma DI
Katso/Avaa
Publisher's version (657.3Kb)
Lataukset: 

doi:10.1073/pnas.1605334113
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042716231
Tiivistelmä

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ∼2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

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