Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort

Sharma A; Liu X; Hadley D; Hagopian W; Liu E; Chen WM; Onengut-Gumuscu S; Simell V; Rewers M; Ziegler AG; Lernmarklo A; Simell O; Toppari J; Krischer JP; Akolkar B; Rich SS; Agardh D; She JX; Teddy Study group
Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort

Sharma A
Liu X
Hadley D
Hagopian W
Liu E
Chen WM
Onengut-Gumuscu S
Simell V
Rewers M
Ziegler AG
Lernmarklo A
Simell O
Toppari J
Krischer JP
Akolkar B
Rich SS
Agardh D
She JX
Teddy Study group
Katso/Avaa
Lataukset: 

PUBLIC LIBRARY SCIENCE
doi:10.1371/journal.pone.0152476
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042714787
Tiivistelmä


In conclusion, using a genetic analysis of a large international cohort of children, we associated celiac disease development with 5 non-HLA regions previously associated with the disease and 8 regions not previously associated with celiac disease. We identified 5 regions associated with development of tTGA. Two loci associated with celiac disease progression reached a genome-wide association threshold in subjects from Sweden.

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