Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort
Ziegler AG; Toppari J; Agardh D; Lernmarklo A; Akolkar B; Sharma A; Rich SS; Liu E; Rewers M; Krischer JP; Simell O; She JX; Teddy Study group; Simell V; Hadley D; Chen WM; Onengut-Gumuscu S; Hagopian W; Liu X
In conclusion, using a genetic analysis of a large international cohort of children, we associated celiac disease development with 5 non-HLA regions previously associated with the disease and 8 regions not previously associated with celiac disease. We identified 5 regions associated with development of tTGA. Two loci associated with celiac disease progression reached a genome-wide association threshold in subjects from Sweden.
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