Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu; Yunzhan Li; Wei Li; Wenhua Lian; Marianna Kemell; Sami Hietala; Patrícia Figueiredo; Li Li; Ermei Mäkilä; Ming Ma; Jarno Salonen; Jouni T. Hirvonen; Dongfei Liu; Hongbo Zhang; Xianming Deng; Hélder A. Santos
Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu
Yunzhan Li
Wei Li
Wenhua Lian
Marianna Kemell
Sami Hietala
Patrícia Figueiredo
Li Li
Ermei Mäkilä
Ming Ma
Jarno Salonen
Jouni T. Hirvonen
Dongfei Liu
Hongbo Zhang
Xianming Deng
Hélder A. Santos
Katso/Avaa
Lataukset: 

ROYAL SOC CHEMISTRY
doi:10.1039/c8mh01145a
URI
https://pubs.rsc.org/en/Content/ArticleLanding/2019/MH/C8MH01145A#!divAbstract
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825528
Tiivistelmä
Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.
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