Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu; Wei Li; Ming Ma; Marianna Kemell; Dongfei Liu; Wenhua Lian; Jarno Salonen; Hélder A. Santos; Jouni T. Hirvonen; Yunzhan Li; Sami Hietala; Li Li; Patrícia Figueiredo; Hongbo Zhang; Xianming Deng; Ermei Mäkilä
Close-loop dynamic nanohybrids on collagen-ark with in situ gelling transformation capability for biomimetic stage-specific diabetic wound healing

Zehua Liu
Wei Li
Ming Ma
Marianna Kemell
Dongfei Liu
Wenhua Lian
Jarno Salonen
Hélder A. Santos
Jouni T. Hirvonen
Yunzhan Li
Sami Hietala
Li Li
Patrícia Figueiredo
Hongbo Zhang
Xianming Deng
Ermei Mäkilä
Katso/Avaa
Lataukset: 

ROYAL SOC CHEMISTRY
doi:10.1039/c8mh01145a
URI
https://pubs.rsc.org/en/Content/ArticleLanding/2019/MH/C8MH01145A#!divAbstract
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825528
Tiivistelmä
Here, an oxidation/acid dual-responsive nanohybrids/ark system was produced. The microfluidics-produced nanohybrids endow the system with an orchestrated cascade from wound detection, reactive oxygen species scavenging, drug release to hydrogel formation. The drug release behavior imitates the dynamic wound healing process, thus rendering an enhanced bio-mimetic regeneration.
Kokoelmat