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RANKL regulates male reproductive function

Jensen Martin Blomberg; Boisen Ida Marie; Lanske Beate; Mortensen Li Juel; Jørgensen Anne; Toppari Jorma; Schwarz Peter; Baron Roland; Juul Anders; Nielsen John Erik; Andreassen Christine Hjorth

RANKL regulates male reproductive function

Jensen Martin Blomberg
Boisen Ida Marie
Lanske Beate
Mortensen Li Juel
Jørgensen Anne
Toppari Jorma
Schwarz Peter
Baron Roland
Juul Anders
Nielsen John Erik
Andreassen Christine Hjorth
Katso/Avaa
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NATURE RESEARCH
doi:10.1038/s41467-021-22734-8
URI
https://www.nature.com/articles/s41467-021-22734-8
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048969
Tiivistelmä

Infertile men have few treatment options. Here, we demonstrate that the transmembrane receptor activator of NF-kB ligand (RANKL) signaling system is active in mouse and human testis. RANKL is highly expressed in Sertoli cells and signals through RANK, expressed in most germ cells, whereas the RANKL-inhibitor osteoprotegerin (OPG) is expressed in germ and peritubular cells. OPG treatment increases wild-type mouse sperm counts, and mice with global or Sertoli-specific genetic suppression of Rankl have increased male fertility and sperm counts. Moreover, RANKL levels in seminal fluid are high and distinguishes normal from infertile men with higher specificity than total sperm count. In infertile men, one dose of Denosumab decreases RANKL seminal fluid concentration and increases serum Inhibin-B and anti-Mullerian-hormone levels, but semen quality only in a subgroup. This translational study suggests that RANKL is a regulator of male reproductive function, however, predictive biomarkers for treatment-outcome requires further investigation in placebo-controlled studies. There are few treatments for male infertility. Here, the authors show that the receptor activator of NF-kappa B ligand (RANKL) signalling pathway has important functions in sperm production and maturation, improves fertility in male mice and shows potential as a male infertility target.

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