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Serum metabolome associated with severity of acute traumatic brain injury

Büki András; Helmrich Isabel RA Retel; Dickens Alex M; Posti Jussi P; Kråkström Matilda; Tenovuo Olli; Maas Andrew IR; Wang Kevin KW; Menon David K; Czeiter Endre; Hyötyläinen Tuulia; Orešič Matej; Group author: CENTER-TBI Participants and Investigators; Steyerberg Ewout W; Sinioja Tim; Duberg Daniel; Thomas Ilias

Serum metabolome associated with severity of acute traumatic brain injury

Büki András
Helmrich Isabel RA Retel
Dickens Alex M
Posti Jussi P
Kråkström Matilda
Tenovuo Olli
Maas Andrew IR
Wang Kevin KW
Menon David K
Czeiter Endre
Hyötyläinen Tuulia
Orešič Matej; Group author: CENTER-TBI Participants and Investigators
Steyerberg Ewout W
Sinioja Tim
Duberg Daniel
Thomas Ilias
Katso/Avaa
s41467-022-30227-5.pdf (2.842Mb)
Lataukset: 

NATURE PORTFOLIO
doi:10.1038/s41467-022-30227-5
URI
https://www.nature.com/articles/s41467-022-30227-5
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081154899
Tiivistelmä

Traumatic brain injury is associated with changes to the metabolome. Here the authors show that acute traumatic brain injury has distinctive serum metabolic patterns which may suggest protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.

Complex metabolic disruption is a crucial aspect of the pathophysiology of traumatic brain injury (TBI). Associations between this and systemic metabolism and their potential prognostic value are poorly understood. Here, we aimed to describe the serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, and its relationship to severity of injury and patient outcome. We performed a comprehensive metabolomics study in a cohort of 716 patients with TBI and non-TBI reference patients (orthopedic, internal medicine, and other neurological patients) from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We identified panels of metabolites specifically associated with TBI severity and patient outcomes. Choline phospholipids (lysophosphatidylcholines, ether phosphatidylcholines and sphingomyelins) were inversely associated with TBI severity and were among the strongest predictors of TBI patient outcomes, which was further confirmed in a separate validation dataset of 558 patients. The observed metabolic patterns may reflect different pathophysiological mechanisms, including protective changes of systemic lipid metabolism aiming to maintain lipid homeostasis in the brain.

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