SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES
Karskela T; Lonnberg H; Klika KD
SYNTHESIS OF 7-SUBSTITUTED 3-beta-D-RIBOFURANOSYL-3H-IMIDAZO[2,1-i]PURINES
Karskela T
Lonnberg H
Klika KD
INST ORGANIC CHEM AND BIOCHEM
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042715079
https://urn.fi/URN:NBN:fi-fe2021042715079
Tiivistelmä
A method for the synthesis of 7-substituted 3-beta-D-ribofuranosyl-3H-imidazo[2,1-i]purines has been devised whereby compounds were prepared in a few steps from a common intermediate, 3-(2',3'-O-isopropylidene-beta-D-ribofuranosyl)-3H-imidazo[2,1-i]purine-7-carbaldehyde, obtained from the reaction of 2',3'-O-isopropylideneadenosine with bromomalonaldehyde. The formyl group of the carbaldehyde was subsequently reductively aminated and the resulting secondary amines were then further derivatized either by acylation, lactamization or reductive alkylation.
Kokoelmat
- Rinnakkaistallenteet [19207]