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Survey of viral reactivations in elite athletes: A case-control study

Maria F.; Grönroos Wilma; Waris Matti; Valtonen Maarit; Luoto Raakel; Pyöriä Lari; Heinonen Olli J.; Olli; Perdomo; Ruuskanen

dc.contributor.authorMaria F.
dc.contributor.authorGrönroos Wilma
dc.contributor.authorWaris Matti
dc.contributor.authorValtonen Maarit
dc.contributor.authorLuoto Raakel
dc.contributor.authorPyöriä Lari
dc.contributor.authorHeinonen Olli J.
dc.contributor.authorOlli
dc.contributor.authorPerdomo
dc.contributor.authorRuuskanen
dc.date.accessioned2022-10-28T14:16:12Z
dc.date.available2022-10-28T14:16:12Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/170376
dc.description.abstract<p>Exercise-induced immune perturbations have been proposed to increase susceptibility to viral infections. We investigated the replication of persisting viruses as indicators of immune function in elite cross-country skiers after ten months of sustained high-performance exercise. The viruses evaluated, nine human herpesviruses (HHVs) and torque teno virus (TTV), are typically restrained in health but replicate actively in immunosuppressed individuals. We collected sera from 27 Finnish elite cross-country skiers at the end of the competition’s season and 27 matched controls who perform moderate exercise. We quantified all the HHVs and—TTV via highly sensitive qPCRs. To verify equal past exposures between the groups, we assessed the IgG antibody prevalences toward HHV-4 (Epstein–Barr virus, EBV) and HHV-5 (human cytomegalovirus, HCMV). We found equal TTV DNA prevalences in athletes (63%) and controls (63%) and loads with respective geometric means of 1.7 × 103 and 1.2 × 103 copies/mL of serum. Overall, the copy numbers were low and consistent with those of healthy individuals. Neither of the groups presented with herpesvirus viremia despite similar past exposures to HHVs (seroprevalences of EBV 70% vs. 78% and HCMV 52% vs. 44% in athletes and controls, respectively). We found no evidence of increased replication of persistent viruses in elite athletes, arguing against impaired viral immunity due to high-performance exercise.<br></p>
dc.language.isoen
dc.publisherMDPI
dc.titleSurvey of viral reactivations in elite athletes: A case-control study
dc.identifier.urlhttps://doi.org/10.3390/pathogens10060666
dc.identifier.urnURN:NBN:fi-fe2021093049003
dc.relation.volume10
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=kliinisen laitoksen yhteiset|en=Department of Clinical Medicine|
dc.contributor.organizationfi=lastentautioppi|en=Paediatrics and Adolescent Medicine|
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organization-code2607313
dc.contributor.organization-code2607100
dc.contributor.organization-code2607300
dc.converis.publication-id66645551
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/66645551
dc.identifier.eissn2076-0817
dc.identifier.jour-issn2076-0817
dc.okm.affiliatedauthorGrönroos, Wilma
dc.okm.affiliatedauthorHeinonen, Olli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorWaris, Matti
dc.okm.affiliatedauthorLuoto, Raakel
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline315 Sport and fitness sciencesen_GB
dc.okm.discipline315 Liikuntatiedefi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumber666
dc.relation.doi10.3390/pathogens10060666
dc.relation.ispartofjournalPathogens
dc.relation.issue6
dc.year.issued2021


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