Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population
Andres A; Inouye M; Niiranen TJ; Salomaa V; Palmu J; Lahti L; Larson MG; Havulinna AS; Jousilahti P; Mercader K; Jain M; Rong J; Salosensaari A; Cheng SS; Watrous JD; Vasan RS; Lagerborg KA
Eicosanoid Inflammatory Mediators Are Robustly Associated With Blood Pressure in the General Population
Andres A
Inouye M
Niiranen TJ
Salomaa V
Palmu J
Lahti L
Larson MG
Havulinna AS
Jousilahti P
Mercader K
Jain M
Rong J
Salosensaari A
Cheng SS
Watrous JD
Vasan RS
Lagerborg KA
WILEY
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042825848
https://urn.fi/URN:NBN:fi-fe2021042825848
Tiivistelmä
Background Epidemiological and animal studies have associated systemic inflammation with blood pressure (BP). However, the mechanistic factors linking inflammation and BP remain unknown. Fatty acid-derived eicosanoids serve as mediators of inflammation and have been suggested to regulate renal vascular tone, peripheral resistance, renin-angiotensin system, and endothelial function. We hypothesize that specific proinflammatory and anti-inflammatory eicosanoids are linked with BP. Methods and Results We studied a population sample of 8099 FINRISK 2002 participants randomly drawn from the Finnish population register (53% women; mean age, 48±13 years) and, for external validation, a sample of 2859 FHS (Framingham Heart Study) Offspring study participants (55% women; mean age, 66±9 years). Using nontargeted liquid chromatography-mass spectrometry, we profiled 545 distinct high-quality eicosanoids and related oxylipin mediators in plasma. Adjusting for conventional hypertension risk factors, we observed 187 (34%) metabolites that were significantly associated with systolic BP (P
Kokoelmat
- Rinnakkaistallenteet [19207]