dc.contributor.author | Miura Nobuaki | |
dc.contributor.author | Noshiro Daisuke | |
dc.contributor.author | Mizushima Tsunehiro | |
dc.contributor.author | Kageyama Shun | |
dc.contributor.author | Lee Jin-A | |
dc.contributor.author | Ohe Tomoyuki | |
dc.contributor.author | Abe Manabu | |
dc.contributor.author | Motohashi Hozumi | |
dc.contributor.author | Miura Yoshiki | |
dc.contributor.author | Okuda Shujiro | |
dc.contributor.author | Sakimura Kenji | |
dc.contributor.author | Noda Nobuo N | |
dc.contributor.author | Kazuno Saiko | |
dc.contributor.author | Tamura Naoki | |
dc.contributor.author | Ueno Takashi | |
dc.contributor.author | Eskelinen Eeva-Liisa Komatsu Masaaki | |
dc.contributor.author | Ichimura Yoshinobu | |
dc.contributor.author | Waguri Satoshi | |
dc.contributor.author | Gudmundsson Sigurdur Runar | |
dc.contributor.author | Sou Yu-Shin | |
dc.date.accessioned | 2022-10-28T14:23:25Z | |
dc.date.available | 2022-10-28T14:23:25Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/171078 | |
dc.description.abstract | Autophagy contributes to the selective degradation of liquid droplets, including the P-Granule, Ape1-complex and p62/SQSTM1-body, although the molecular mechanisms and physiological relevance of selective degradation remain unclear. In this report, we describe the properties of endogenous p62-bodies, the effect of autophagosome biogenesis on these bodies, and the in vivo significance of their turnover. p62-bodies are low-liquidity gels containing ubiquitin and core autophagy-related proteins. Multiple autophagosomes form on the p62-gels, and the interaction of autophagosome-localizing Atg8-proteins with p62 directs autophagosome formation toward the p62-gel. Keap1 also reversibly translocates to the p62-gels in a p62-binding dependent fashion to activate the transcription factor Nrf2. Mice deficient for Atg8-interaction-dependent selective autophagy show that impaired turnover of p62-gels leads to Nrf2 hyperactivation in vivo. These results indicate that p62-gels are not simple substrates for autophagy but serve as platforms for both autophagosome formation and anti-oxidative stress. | |
dc.language.iso | en | |
dc.publisher | SpringerNature | |
dc.title | p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response | |
dc.identifier.urn | URN:NBN:fi-fe2021042826334 | |
dc.relation.volume | 12 | |
dc.contributor.organization | fi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine| | |
dc.contributor.organization-code | 2607100 | |
dc.converis.publication-id | 51245853 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/51245853 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.jour-issn | 2041-1723 | |
dc.okm.affiliatedauthor | Eskelinen, Eeva-Liisa | |
dc.okm.discipline | 1182 Biokemia, solu- ja molekyylibiologia | fi_FI |
dc.okm.discipline | 1182 Biochemistry, cell and molecular biology | en_GB |
dc.okm.discipline | 3111 Biolääketieteet | fi_FI |
dc.okm.discipline | 3111 Biomedicine | en_GB |
dc.okm.internationalcopublication | international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.publisher.country | Britannia | fi_FI |
dc.publisher.country | United Kingdom | en_GB |
dc.publisher.country-code | GB | |
dc.relation.articlenumber | 16 | |
dc.relation.doi | 10.1038/s41467-020-20185-1 | |
dc.relation.ispartofjournal | Nature Communications | |
dc.relation.issue | 1 | |
dc.year.issued | 2021 | |