Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo
Poutanen M; Alhoniemi E; Suominen MI; Makela S; Savolainen S; Aittokallio T; Corander J; Makela K; Laajala TD; Saarinen NM
Improved Statistical Modeling of Tumor Growth and Treatment Effect in Preclinical Animal Studies with Highly Heterogeneous Responses In Vivo
Poutanen M
Alhoniemi E
Suominen MI
Makela S
Savolainen S
Aittokallio T
Corander J
Makela K
Laajala TD
Saarinen NM
AMER ASSOC CANCER RESEARCH
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042714162
https://urn.fi/URN:NBN:fi-fe2021042714162
Tiivistelmä
Conclusions: In general, the modeling framework enables identification of such biologically significant differences in tumor growth profiles that would have gone undetected or had required considerably higher number of animals when using traditional statistical methods. Clin Cancer Res; 18(16); 4385-96. (C) 2012 AACR.
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