Phylogenetic history of patrilineages rare in northern and eastern Europe from large-scale re-sequencing of human Y-chromosomes
Behar Doron M; Sahakyan Hovhannes; Mondal Mayukh; Karmin Monika; Pagani Luca; Ameur Adam; Saag Lauri; Flores Rodrigo; Kals Mart; Sanchez Luisa Fernanda; Ilumäe Anne-Mai; Villems Richard; Bormans Concetta; Post Helen; Rootsi Siiri; Mägi Reedik; Gyllensten Ulf; Montinaro Francesco
Phylogenetic history of patrilineages rare in northern and eastern Europe from large-scale re-sequencing of human Y-chromosomes
Behar Doron M
Sahakyan Hovhannes
Mondal Mayukh
Karmin Monika
Pagani Luca
Ameur Adam
Saag Lauri
Flores Rodrigo
Kals Mart
Sanchez Luisa Fernanda
Ilumäe Anne-Mai
Villems Richard
Bormans Concetta
Post Helen
Rootsi Siiri
Mägi Reedik
Gyllensten Ulf
Montinaro Francesco
SpringerNature
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021100750285
https://urn.fi/URN:NBN:fi-fe2021100750285
Tiivistelmä
The most frequent Y-chromosomal (chrY) haplogroups in northern and eastern Europe (NEE) are well-known and thoroughly characterised. Yet a considerable number of men in every population carry rare paternal lineages with estimated frequencies around 5%. So far, limited sample-sizes and insufficient resolution of genotyping have obstructed a truly comprehensive look into the variety of rare paternal lineages segregating within populations and potential signals of population history that such lineages might convey. Here we harness the power of massive re-sequencing of human Y chromosomes to identify previously unknown population-specific clusters among rare paternal lineages in NEE. We construct dated phylogenies for haplogroups E2-M215, J2-M172, G-M201 and Q-M242 on the basis of 421 (of them 282 novel) high-coverage chrY sequences collected from large-scale databases focusing on populations of NEE. Within these otherwise rare haplogroups we disclose lineages that began to radiate similar to 1-3 thousand years ago in Estonia and Sweden and reveal male phylogenetic patterns testifying of comparatively recent local demographic expansions. Conversely, haplogroup Q lineages bear evidence of ancient Siberian influence lingering in the modern paternal gene pool of northern Europe. We assess the possible direction of influx of ancestral carriers for some of these male lineages. In addition, we demonstrate the congruency of paternal haplogroup composition of our dataset with two independent population-based cohorts from Estonia and Sweden.
Kokoelmat
- Rinnakkaistallenteet [19207]