Non-Adherence to Statin Treatment in Older Patients with Peripheral Arterial Disease Depending on Persistence Status
Murin Jan; Matalova Petra; Tesar Tomas; Wawruch Martin; Trnka Michal; Wimmer Gejza; Aarnio Emma; Petrova Miriam; Havelkova Beata; Paduchova Martina
Non-Adherence to Statin Treatment in Older Patients with Peripheral Arterial Disease Depending on Persistence Status
Murin Jan
Matalova Petra
Tesar Tomas
Wawruch Martin
Trnka Michal
Wimmer Gejza
Aarnio Emma
Petrova Miriam
Havelkova Beata
Paduchova Martina
MDPI
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042826980
https://urn.fi/URN:NBN:fi-fe2021042826980
Tiivistelmä
The effectiveness of statins in secondary prevention of peripheral arterial disease (PAD) largely depends on patients' adherence to treatment. The aims of our study were: (a) to analyze non-adherence during the whole follow-up in persistent patients, and only during persistence for non-persistent patients; (b) to identify factors associated with non-adherence separately among persistent and non-persistent patients. A cohort of 8330 statin users aged >= 65 years, in whom PAD was newly diagnosed between January 2012-December 2012, included 5353 patients persistent with statin treatment, and 2977 subjects who became non-persistent during the 5-year follow-up. Non-adherence was defined using the proportion of days covered <80%. Patient- and statin-related characteristics associated with non-adherence were identified with binary logistic regression. A significantly higher proportion of non-adherent patients was found among non-persistent patients compared to persistent subjects (43.6% vs. 29.6%; p < 0.001). Associated with non-adherence in both persistent and non-persistent patients was high intensity statin treatment, while in non-persistent patients, it was employment and increasing number of medications. In patients with a poor adherence during their persistent period, an increased risk for discontinuation may be expected. However, there is also non-adherence among persistent patients. There are differences in factors associated with non-adherence depending on patients' persistence.
Kokoelmat
- Rinnakkaistallenteet [19207]