Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei
Annika Brünje; Paula Mulo; Ines Lassowskat; Priyadarshini Tilak; Iris Finkemeier; Dario Leister; Minna M. Koskela; Guillaume Née; Jonas Giese; Magdalena Füßl; Dirk Schwarzer
Beyond Histones: New Substrate Proteins of Lysine Deacetylases in Arabidopsis Nuclei
Annika Brünje
Paula Mulo
Ines Lassowskat
Priyadarshini Tilak
Iris Finkemeier
Dario Leister
Minna M. Koskela
Guillaume Née
Jonas Giese
Magdalena Füßl
Dirk Schwarzer
FRONTIERS MEDIA SA
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042719108
https://urn.fi/URN:NBN:fi-fe2021042719108
Tiivistelmä
The reversible acetylation of lysine residues is catalyzed by the antagonistic action of lysine acetyltransferases and deacetylases, which can be considered as master regulators of their substrate proteins. Lysine deacetylases, historically referred to as histone deacetylases, have profound functions in regulating stress defenses and development in plants. Lysine acetylation of the N-terminal histone tails promotes gene transcription and decondensation of chromatin, rendering the DNA more accessible to the transcription machinery. In plants, the classical lysine deacetylases from the RPD3/HDA1-family have thus far mainly been studied in the context of their deacetylating activities on histones, and their versatility in molecular activities is still largely unexplored. Here we discuss the potential impact of lysine acetylation on the recently identified nuclear substrate proteins of lysine deacetylases from the Arabidopsis RPD3/HDA1-family. Among the deacetylase substrate proteins, many interesting candidates involved in nuclear protein import, transcriptional regulation, and chromatin remodeling have been identified. These candidate proteins represent key starting points for unraveling new molecular functions of the Arabidopsis lysine deacetylases. Site-directed engineering of lysine acetylation sites on these target proteins might even represent a new approach for optimizing plant growth under climate change conditions.
Kokoelmat
- Rinnakkaistallenteet [19207]