Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Harris S; Al Olama AA; Farrington S; Paul J; Jenkins ME; Sud A; Giles GG; Holroyd A; Arnold R; Menegaux F; Matosevic P; De Ruyck K; Dunlop MG; Gapstur S; Johnstone E; Easton DF; Ingles SA; Hamdy FC; Swerdlow A; Martin L; Canzian F; Pinna M; Chang-Claude J; West C; Kaneva R; Leedham S; Muir K; Neuhausen SL; Palin K; Hoffmann P; Hofer P; Cybulski C; Mecklin JP; Gronberg H; Nordestgaard BG; Hoffmeister M; Timofeeva M; Tomlinson I; Kaasinen E; Park JY; Ripatti S; Eeles RA; Studd J; Kogevinas M; Kaplan R; Knekt P; Eriksson JG; Saunders M; Casey G; Gsur A; Kerr R; Al-Tassan N; Chanock S; Sarin AP; Travis RC; Vega A; Newcomb LF; Iveson T; Roobol MJ; Pharoah PDP; Zgaga L; Palotie A; Bohm J; Grindeda EM; Schleutker J; Lindor NM; Peto J; Wang H; Hayward C; Claessens F; Lepisto A; John EM; Penegar S; Broderick P; Conti DV; Maier C; Jousilahti P; Neal DE; Khaw KT; Tanskanen T; Wiklund F; Tangen CM; Kote-Jarai Z; Allan K; Hopper J; Thibodeau SN; Cannon-Albright L; Campbell H; Sharma-Oates A; Orlando G; Duggan D; Koutros S; Nothen MM; Newcomb PA; Svinti V; Hamilton RJ; Briggs S; Lu YJ; Cajuso T; Houlston RS; Renkonen-Sinisalo L; Kim J; Fernandez-Rozadilla C; Cheadle JP; Henderson BE; Butterbach K; Razack A; Salomaa V; Schumacher FR; Kibel AS; Cancel-Tassin G; Rissanen H; Gamulin M; Batra J; East J; Clements J; Mucci L; Aaltonen LA; Gallinger S; Usmani N; Townsend PA; Deary IJ; Stevens VL; Wolk A; Brenner H; Pashayan N; Jockel KH; Starr O; Albanes D; Teixeira MR; Kirac I; Timofeeva A; Win AK; Donovan JL; Sorensen KD; Brezina S; McQueen J; Hanninen UA; Benlloch S; Pandha H; Theodoratou E; Kondelin J; Stanford JL; Rosenstein BS; Kerr D; Fernandez-Tajes J; Penney KL; Campbell A; Gatcombe L; Law PJ; Palles C; Maughan T; Pukkala E; Gago-Dominguez M; Buchanan DD; Vaughan-Shaw P; Harkin A; Haiman CA; Jaeger E; Berndt SI
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042827199
https://urn.fi/URN:NBN:fi-fe2021042827199
Tiivistelmä
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
Kokoelmat
- Rinnakkaistallenteet [19207]