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Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration

Cheng Ruoyu; Zhang Lu; Santos Hélder A; Deng Lianfu; Zhang Yuguang; Zhang Hongbo; Cheng Liying; Cui Wenguo; Sun Xiaoming; Bae Jinhong; Mao Xiyuan

Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration

Cheng Ruoyu
Zhang Lu
Santos Hélder A
Deng Lianfu
Zhang Yuguang
Zhang Hongbo
Cheng Liying
Cui Wenguo
Sun Xiaoming
Bae Jinhong
Mao Xiyuan
Katso/Avaa
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Lataukset: 

Wiley Online Library
doi:10.1002/advs.201801555
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042720627
Tiivistelmä

The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing–promoting properties that match the dynamic healing process of skin flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF-Lip@PEG) is developed for clinical applications through Ag–S coordination of four-arm-PEG-SH and Ag+. Compared to MF-PEG, MF-Lip@PEG exhibits self-healing properties, lower swelling percentages, and a longer endurance period. Moreover, the hydrogel exhibits excellent drug dispersibility and release characteristics for slow and persistent drug delivery. In vitro studies show that the hydrogel is biocompatible and nontoxic to cells, and exerts an outstanding neovascularization-promoting effect. The MF-Lip@PEG also exhibits a strong cytoprotective effect against hypoxia-induced apoptosis through regulation of the Bax/Bcl-2/caspase-3 pathway. In a random skin flap animal model, the MF-Lip@PEG is injectable and convenient to deliver into the skin flap, providing excellent anti-inflammation, anti-infection, and proneovascularization effects and significantly reducing the skin flap necrosis rate. In general, the MF-Lip@PEG possesses outstanding multifunctionality for the dynamic healing process of skin flap regeneration.

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