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Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene

Tammela OKT; Poets CF; Delacourt C; Hadchouel A; Huusko JM; Andersson S; Kari MA; Karjalainen MK; Bassler D; Muglia LJ; Hallman M; Sankilampi U; Ramet M; Palotie A; Lehtonen L; Mahlman M; Danan C; Lacaze-Masmonteil T; Marttila RH; Lavoie PM

Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene

Tammela OKT
Poets CF
Delacourt C
Hadchouel A
Huusko JM
Andersson S
Kari MA
Karjalainen MK
Bassler D
Muglia LJ
Hallman M
Sankilampi U
Ramet M
Palotie A
Lehtonen L
Mahlman M
Danan C
Lacaze-Masmonteil T
Marttila RH
Lavoie PM
Katso/Avaa
Publisher's version (1.622Mb)
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NATURE PUBLISHING GROUP
doi:10.1038/s41598-017-08977-w
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042717184
Tiivistelmä
Bronchopulmonary dysplasia (BPD), the main consequence of prematurity, has a significant heritability, but little is known about predisposing genes. The aim of this study was to identify gene loci predisposing infants to BPD. The initial genome-wide association study (GWAS) included 174 Finnish preterm infants of gestational age 24-30 weeks. Thereafter, the most promising single-nucleotide polymorphisms (SNPs) associated with BPD were genotyped in both Finnish (n = 555) and non-Finnish (n = 388) replication cohorts. Finally, plasma CRP levels from the first week of life and the risk of BPD were assessed. SNP rs11265269, flanking the CRP gene, showed the strongest signal in GWAS (odds ratio [ OR] 3.2, p = 3.4 x 10(-6)). This association was nominally replicated in Finnish and French African populations. A number of other SNPs in the CRP region, including rs3093059, had nominal associations with BPD. During the first week of life the elevated plasma levels of CRP predicted the risk of BPD (OR 3.4, p = 2.9 x 10(-4)) and the SNP rs3093059 associated nominally with plasma CRP levels. Finally, SNP rs11265269 was identified as a risk factor of BPD (OR 1.8, p = 5.3 x 10(-5)), independently of the robust antenatal risk factors. As such, in BPD, a potential role for variants near CRP gene is proposed.
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