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Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort

Brennan Lorraine; Hyötyläinen Tuulia; Yin Xiaofei; Zammit Stanley; Cotter David R; Cannon Mary; Mongan David; Orešič Matej

Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort

Brennan Lorraine
Hyötyläinen Tuulia
Yin Xiaofei
Zammit Stanley
Cotter David R
Cannon Mary
Mongan David
Orešič Matej
Katso/Avaa
OresicEtAl2022PlasmaLipidAlterations.pdf (504.6Kb)
Lataukset: 

Elsevier B.V.
doi:10.1016/j.schres.2022.02.029
URI
https://doi.org/10.1016/j.schres.2022.02.029
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081155122
Tiivistelmä

Background

Psychotic experiences (PEs) are associated with an increased risk of future psychotic and non-psychotic mental disorders. The identification of biomarkers of PEs may provide insights regarding the underlying pathophysiology.

Methods

The current study applied targeted lipidomic approaches to compare plasma lipid profiles in participants from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort who did (n = 206) or did not (n = 206) have PEs when aged approximately 24 years.

Results

In total, 202 lipids including 8 lipid classes were measured by using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS). Eight lipid clusters were generated. Thirteen individual lipids were nominally significantly higher in the PEs group compared to the control group. After correction for multiple comparisons, 9 lipids comprising 3 lysophosphatidylcholines (LPCs), 2 phosphatidylcholines (PCs) and 4 triacylglycerols (TGs) remained significant. In addition, PEs cases had increased levels of TGs and LPCs with a low double bond count.

Conclusions

These findings indicate plasma lipidomic abnormalities in individuals experiencing PEs. The lipidomic profile measures could aid our understanding of the underlying pathophysiological mechanisms.

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