Näytä suppeat kuvailutiedot

Varying outcomes of triple-negative breast cancer in different age groups-prognostic value of clinical features and proliferation

Repo Heli; Talvinen Kati; Autere Tuomi-Artturi; Vihervuori Hilda; Kronqvist Pauliina; Korpinen Katarina

dc.contributor.authorRepo Heli
dc.contributor.authorTalvinen Kati
dc.contributor.authorAutere Tuomi-Artturi
dc.contributor.authorVihervuori Hilda
dc.contributor.authorKronqvist Pauliina
dc.contributor.authorKorpinen Katarina
dc.date.accessioned2022-11-29T15:43:34Z
dc.date.available2022-11-29T15:43:34Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/173175
dc.description.abstract<p>Purpose<br>Triple-negative breast cancer (TNBC) is an aggressive disease lacking specific biomarkers to guide treatment decisions. We evaluated the combined prognostic impact of clinical features and novel biomarkers of cell cycle-progression in age-dependent subgroups of TNBC patients.</p><p>Methods<br>One hundred forty seven TNBC patients with complete clinical data and up to 18 year follow-up were collected from Turku University Hospital, Finland. Eight biomarkers for cell division were immunohistochemically detected to evaluate their clinical applicability in relation to patient and tumor characteristics.</p><p>Results<br>Age at diagnosis was the decisive factor predicting disease-specific mortality in TNBC (<i>p</i> = 0.002). The established prognostic features, nodal status and Ki-67, predicted survival only when combined with age. The outcome and prognostic features differed significantly between age groups, middle-aged patients showing the most favorable outcome. Among young patients, only lack of basal differentiation predicted disease outcome, indicating 4.5-fold mortality risk (<i>p</i> = 0.03). Among patients aged > 57, the established prognostic features predicted disease outcome with up to 3.0-fold mortality risk for tumor size ≥ 2 cm (<i>p</i> = 0.001). Concerning cell proliferation, Ki-67 alone was a significant prognosticator among patients aged > 57 years (<i>p</i> = 0.009). Among the studied cell cycle-specific biomarkers, only geminin predicted disease outcome, indicating up to 6.2-fold increased risk of mortality for tumor size < 2 cm (<i>p</i> = 0.03).</p><p>Conclusion<br>Traditional clinical features do not provide optimal prognostic characterization for all TNBC patients. Young age should be considered as an additional adverse prognostic feature in therapeutic considerations. Increased proliferation, as evaluated using Ki-67 or geminin immunohistochemistry, showed potential in detecting survival differences in subgroups of TNBC.</p>
dc.language.isoen
dc.publisherSPRINGER
dc.titleVarying outcomes of triple-negative breast cancer in different age groups-prognostic value of clinical features and proliferation
dc.identifier.urlhttp://dx.doi.org/10.1007%2Fs10549-022-06767-1
dc.identifier.urnURN:NBN:fi-fe2022112967641
dc.relation.volume196
dc.contributor.organizationfi=psykiatria|en=Psychiatry|
dc.contributor.organizationfi=biolääketieteen laitos, yhteiset|en=Institute of Biomedicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organization-code2607316
dc.contributor.organization-code2607100
dc.converis.publication-id177016342
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/177016342
dc.format.pagerange482
dc.format.pagerange471
dc.identifier.eissn1573-7217
dc.identifier.jour-issn0167-6806
dc.okm.affiliatedauthorTalvinen, Kati
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorKorpinen, Katarina
dc.okm.affiliatedauthorVihervuori, Hilda
dc.okm.affiliatedauthorKronqvist, Pauliina
dc.okm.affiliatedauthorAutere, Tuomo-Artturi
dc.okm.discipline3122 Cancersen_GB
dc.okm.discipline3122 Syöpätauditfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.doi10.1007/s10549-022-06767-1
dc.relation.ispartofjournalBreast Cancer Research and Treatment
dc.relation.issue3
dc.year.issued2022


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot