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A larger brown fat volume and lower radiodensity are related to a greater cardiometabolic risk, especially in young men

Acosta Francisco M; Aguilera Concepcion M; Gil Angel; Ruiz Jonatan R; Mendez-Gutierrez Andrea; Llamas-Elvira Jose M; Osuna-Prieto Francisco J; Martinez-Tellez Borja; Sanchez-Delgado Guillermo

dc.contributor.authorAcosta Francisco M
dc.contributor.authorAguilera Concepcion M
dc.contributor.authorGil Angel
dc.contributor.authorRuiz Jonatan R
dc.contributor.authorMendez-Gutierrez Andrea
dc.contributor.authorLlamas-Elvira Jose M
dc.contributor.authorOsuna-Prieto Francisco J
dc.contributor.authorMartinez-Tellez Borja
dc.contributor.authorSanchez-Delgado Guillermo
dc.date.accessioned2022-11-29T15:44:29Z
dc.date.available2022-11-29T15:44:29Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/173200
dc.description.abstract<p><em>Objectives</em>: Brown adipose tissue (BAT) is important in the maintenance of cardiometabolic health in rodents. Recent reports appear to suggest the same in humans, although if this is true remains elusive partly because of the methodological bias that affected previous research. This cross-sectional work reports the relationships of cold-induced BAT volume, activity (peak standardized uptake, SUVpeak), and mean radiodensity (an inverse proxy of the triacylglycerols content) with the cardiometabolic and inflammatory profile of 131 young adults, and how these relationships are influenced by sex and body weight.<br></p><p><em>Design</em>: This is a cross-sectional study.Methods: Subjects underwent personalized cold exposure for 2 h to activate BAT, followed by static F-18-fluorodeoxyglucose PET-CT scanning to determine BAT variables. Information on cardiometabolic risk (CMR) and inflammatory markers was gathered, and a CMR score and fatty liver index (FLI) were calculated.</p><p><em>Results</em>: In men, BAT volume was positively related to homocysteine and liver damage markers concentrations (independently of BMI and seasonality) and the FLI (all P <= 0.05). In men, BAT mean radiodensity was negatively related to the glucose and insulin concentrations, alanine aminotransfe rase activity, insulin resistance, total cholesterol/HDL-C, LDL-C/HDL-C, the CMR score, and the FLI (all P <= 0.02). In women, it was only negatively related to the FLI (P < 0.001). These associations were driven by the results for the overweight and obese subjects. No relationship was seen between BAT and inflammatory markers (P > 0.05).</p><p><em>Conclusions</em>: A larger BAT volume and a lower BAT mean radiodensity are related to a higher CMR, especially in young men, which may support that BAT acts as a compensatory organ in states of metabolic disruption.</p>
dc.language.isoen
dc.publisherBioScientifica
dc.titleA larger brown fat volume and lower radiodensity are related to a greater cardiometabolic risk, especially in young men
dc.identifier.urlhttps://doi.org/10.1530/EJE-22-0130
dc.identifier.urnURN:NBN:fi-fe2022112967734
dc.relation.volume187
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organizationfi=InFLAMES lippulaiva, tutkimus|en=InFLAMES Flagship, research|
dc.contributor.organizationfi=PET tutkimus|en=PET Research|
dc.contributor.organization-code2609820
dc.converis.publication-id177021990
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/177021990
dc.format.pagerange183
dc.format.pagerange171
dc.identifier.eissn1479-683X
dc.identifier.jour-issn0804-4643
dc.okm.affiliatedauthorDataimport, 2607051 InFLAMES lippulaiva, tutkimus
dc.okm.affiliatedauthorAcosta Manzano, Francisco
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryBritanniafi_FI
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.country-codeGB
dc.relation.doi10.1530/EJE-22-0130
dc.relation.ispartofjournalEuropean Journal of Endocrinology
dc.relation.issue1
dc.year.issued2022


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