Determinants of serum EPA and DHA in four serum lipid fractions during pregnancy
Ojaniemi, Marja (2023-04-05)
Determinants of serum EPA and DHA in four serum lipid fractions during pregnancy
(05.04.2023)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2023041236060
https://urn.fi/URN:NBN:fi-fe2023041236060
Tiivistelmä
Objective Mother’s blood serum fatty acids are important factors in foetal development. Especially docosahexaenoic acid (DHA) is necessary to neural development. Fish is a great dietary source of DHA and also eicosapentaenoic acid (EPA), which is another important fatty acid.
Design Venous fasting blood samples, 3-day-food diary and questionnaires were collected from 439 mothers in their early pregnancy (mean 13.8 gestational weeks, SD 2.1). Statistical methods were used to study how different variables affect mother’s blood serum DHA and EPA concentrations and percentages in four different blood lipid fractions: triacylglycerols, cholesterol esters, phospholipids and non esterified fatty acids (NEFAs).
Results Diet, medical status (such as inflammation and gestational weeks) and lifestyle habits (such as smoking and education) correlated to serum DHA and EPA. Especially fish eating had an increasing effect in all four lipid fractions. Some variables had a statistically significant effect in some fractions but not in others, for example inflammation markers (CRP and GlycA) in phospholipids but not in NEFAs.
Conclusions Mothers’ FA status can be improved with dietary and lifestyle choices. Different lipids fractions show similar results in some variables and different in others. It is important to study what factors affect blood serum fatty acids and what is significant to health and normal foetal development. More studies are needed to better understand these correlations and their mechanisms.
Design Venous fasting blood samples, 3-day-food diary and questionnaires were collected from 439 mothers in their early pregnancy (mean 13.8 gestational weeks, SD 2.1). Statistical methods were used to study how different variables affect mother’s blood serum DHA and EPA concentrations and percentages in four different blood lipid fractions: triacylglycerols, cholesterol esters, phospholipids and non esterified fatty acids (NEFAs).
Results Diet, medical status (such as inflammation and gestational weeks) and lifestyle habits (such as smoking and education) correlated to serum DHA and EPA. Especially fish eating had an increasing effect in all four lipid fractions. Some variables had a statistically significant effect in some fractions but not in others, for example inflammation markers (CRP and GlycA) in phospholipids but not in NEFAs.
Conclusions Mothers’ FA status can be improved with dietary and lifestyle choices. Different lipids fractions show similar results in some variables and different in others. It is important to study what factors affect blood serum fatty acids and what is significant to health and normal foetal development. More studies are needed to better understand these correlations and their mechanisms.