A quantitative and qualitative analysis of Positron Emission Tomography (PET) in Yttrium-90 radioembolization; investigating the utility of PET dosimetry in identifying sites of necrosis and viable tumor
Anbari Yazdi, Yasaman (2023-08-03)
A quantitative and qualitative analysis of Positron Emission Tomography (PET) in Yttrium-90 radioembolization; investigating the utility of PET dosimetry in identifying sites of necrosis and viable tumor
(03.08.2023)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
avoin
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe20230911122199
https://urn.fi/URN:NBN:fi-fe20230911122199
Tiivistelmä
Purpose: PET imaging is becoming more common for verifying the location of 90Y microspheres during liver cancer treatment. The work aims to predict which patients will likely to have remaining viable tumors based on the 90Y PET image taken right after the radioembolization.
Methods: 10 hepatocellular carcinoma (HCC) patients treated by radioembolization with 90Y glass microspheres were included in this study. Post-treatment PET was coregistered with the follow-up image to investigate the correlation between the isodose contours based on the post-treatment PET image and the necrosis and viable tumor on the follow-up image. To evaluate the similarity quantitatively, isodose contours derived from 90Y PET and necrosis area on the follow-up image were compared using the Dice similarity coefficient. In addition to the quantitative assessment, a qualitative assessment of a 1–5-point scale was utilized to rate the correlation of underdose regions on the post-treatment PET and the viable tumor on the follow-up. The study thereby provided insights into the interpretation and analysis of post-radioembolization imaging in HCC patients.
Results: The findings in this retrospective study with 10 patients included for quantitative assessment suggest an isodose range of 250 Gy to 300 Gy yields the best match for the necrosis site. Also, the qualitative assessment of these 10 patients shows a median agreement of 4 on a 1–5-point scale.
Conclusion: 90Y PET/CT evaluation and dosimetry add clinical benefit to patient treatments by locating untreated tumors and potential sites of recurrence.
Methods: 10 hepatocellular carcinoma (HCC) patients treated by radioembolization with 90Y glass microspheres were included in this study. Post-treatment PET was coregistered with the follow-up image to investigate the correlation between the isodose contours based on the post-treatment PET image and the necrosis and viable tumor on the follow-up image. To evaluate the similarity quantitatively, isodose contours derived from 90Y PET and necrosis area on the follow-up image were compared using the Dice similarity coefficient. In addition to the quantitative assessment, a qualitative assessment of a 1–5-point scale was utilized to rate the correlation of underdose regions on the post-treatment PET and the viable tumor on the follow-up. The study thereby provided insights into the interpretation and analysis of post-radioembolization imaging in HCC patients.
Results: The findings in this retrospective study with 10 patients included for quantitative assessment suggest an isodose range of 250 Gy to 300 Gy yields the best match for the necrosis site. Also, the qualitative assessment of these 10 patients shows a median agreement of 4 on a 1–5-point scale.
Conclusion: 90Y PET/CT evaluation and dosimetry add clinical benefit to patient treatments by locating untreated tumors and potential sites of recurrence.