Heavy smoking increases the risk of malignant transformation of sinonasal inverted papilloma
Willgren, Ida (2025-04-11)
Heavy smoking increases the risk of malignant transformation of sinonasal inverted papilloma
(11.04.2025)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
suljettu
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2025042531225
https://urn.fi/URN:NBN:fi-fe2025042531225
Tiivistelmä
Objective: This study aims to explore the characteristics of sinonasal inverted papilloma (SNIP) associated with recurrence and malignant transformation.
Material and Methods: A retrospective study was performed with patients (n = 182) diagnosed with inverted papilloma between years 2004 and 2023 at Turku University Hospital (TYKS). Patient demographic data, smoking habits, tumor location, surgical technique, number of recurrences, association with squamous cell carcinoma (SCC) and follow-up details were collected.
Results: The statistical analyses were made with a total of 144 patients who fulfilled the inclusion criteria. The mean age of these patients was 56.4 years. The male-to-female ratio was 2.1:1. The mean follow-up period was 6.0 years. Twenty-nine patients (29/144, 20.1 %) experienced recurrence, in mean time of 5.8 years. The recurrence rate was significantly lower with the endoscopic approach compared to both open and combined approaches (p < 0.0001). Ten patients (6.9 %) were diagnosed with SCC. Of these, four patients (4/144, 2.8 %; 4/10, 40.0 %) were diagnosed with synchronous carcinoma, while six patients (6/144, 4.2 %; 6/10, 60.0 %) developed metachronous carcinoma. Heavy smoking (over 10 years) was associated with the increased risk of the malignant transformation from SNIP to SCC (Odds ratio = 5.0, 95 % CI 1.0 to 24.3). Recurrence of inverted papilloma was associated with lower overall survival, even when SCC cases were excluded from the analysis
Conclusion: History of smoking is associated with the malignant transformation of sinonasal inverted papilloma. The endoscopic approach has significantly lower recurrence rate compared to both open and combined approaches. Therefore, the endoscopic approach should be preferred as the primary treatment method for sinonasal inverted papilloma.
Material and Methods: A retrospective study was performed with patients (n = 182) diagnosed with inverted papilloma between years 2004 and 2023 at Turku University Hospital (TYKS). Patient demographic data, smoking habits, tumor location, surgical technique, number of recurrences, association with squamous cell carcinoma (SCC) and follow-up details were collected.
Results: The statistical analyses were made with a total of 144 patients who fulfilled the inclusion criteria. The mean age of these patients was 56.4 years. The male-to-female ratio was 2.1:1. The mean follow-up period was 6.0 years. Twenty-nine patients (29/144, 20.1 %) experienced recurrence, in mean time of 5.8 years. The recurrence rate was significantly lower with the endoscopic approach compared to both open and combined approaches (p < 0.0001). Ten patients (6.9 %) were diagnosed with SCC. Of these, four patients (4/144, 2.8 %; 4/10, 40.0 %) were diagnosed with synchronous carcinoma, while six patients (6/144, 4.2 %; 6/10, 60.0 %) developed metachronous carcinoma. Heavy smoking (over 10 years) was associated with the increased risk of the malignant transformation from SNIP to SCC (Odds ratio = 5.0, 95 % CI 1.0 to 24.3). Recurrence of inverted papilloma was associated with lower overall survival, even when SCC cases were excluded from the analysis
Conclusion: History of smoking is associated with the malignant transformation of sinonasal inverted papilloma. The endoscopic approach has significantly lower recurrence rate compared to both open and combined approaches. Therefore, the endoscopic approach should be preferred as the primary treatment method for sinonasal inverted papilloma.