INCREASED FRONTAL SEROTONERGIC FUNCTION IN PARKINSON’S DISEASE PATIENTS WITH SELF-REPORTED REM SLEEP BEHAVIOR DISORDER
Ijas, Jani (2025-04-24)
INCREASED FRONTAL SEROTONERGIC FUNCTION IN PARKINSON’S DISEASE PATIENTS WITH SELF-REPORTED REM SLEEP BEHAVIOR DISORDER
(24.04.2025)
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty.
avoin
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2025042933243
https://urn.fi/URN:NBN:fi-fe2025042933243
Tiivistelmä
Rapid eye movement (REM) sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson’s disease (PD) and a potential early marker of synucleinopathy-related neurodegeneration. While striatal dopaminergic dysfunction in PD-RBD has been extensively studied, the role of extrastriatal monoaminegic alterations -particularly serotonergic - remains poorly understood.
In this study, 155 PD patients underwent [123I]FP-CIT SPECT imaging to assess striatal and extrastriatal tracer binding, reflecting dopaminergic and serotonergic function, respectively. Probable RBD was identified using a validated single-question screening tool with high sensitivity and specificity. Patients with probable RBD (RBD+, n=44) were compared to those without (RBD−, n=111) using voxel-wise and region-of-interest analyses, controlling for age, sex, disease duration, motor and non-motor symptom severity, and cognitive function.
No significant differences were observed in striatal dopamine transporter binding. However, RBD+ patients showed significantly higher extrastriatal binding in the prefrontal cortex (pFWE<0.05), suggesting a role for altered serotonergic neurotransmission in PD-RBD pathophysiology.
In this study, 155 PD patients underwent [123I]FP-CIT SPECT imaging to assess striatal and extrastriatal tracer binding, reflecting dopaminergic and serotonergic function, respectively. Probable RBD was identified using a validated single-question screening tool with high sensitivity and specificity. Patients with probable RBD (RBD+, n=44) were compared to those without (RBD−, n=111) using voxel-wise and region-of-interest analyses, controlling for age, sex, disease duration, motor and non-motor symptom severity, and cognitive function.
No significant differences were observed in striatal dopamine transporter binding. However, RBD+ patients showed significantly higher extrastriatal binding in the prefrontal cortex (pFWE<0.05), suggesting a role for altered serotonergic neurotransmission in PD-RBD pathophysiology.