Nutritional metabolomics: Recent developments and future needs

Abstract

<div><p><a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/metabolomics" title="Learn more about Metabolomics from ScienceDirect's AI-generated Topic Pages">Metabolomics</a> has rapidly been adopted as one of the key methods in nutrition research. This review focuses on the recent developments and updates in the field, including the analytical methodologies that encompass improved instrument sensitivity, sampling techniques and data integration (multiomics). Metabolomics has advanced the discovery and validation of dietary biomarkers and their implementation in health research. Metabolomics has come to play an important role in the understanding of the role of <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/small-molecule" title="Learn more about small molecules from ScienceDirect's AI-generated Topic Pages">small molecules</a> resulting from the diet–microbiota interactions when gut <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/microflora" title="Learn more about microbiota from ScienceDirect's AI-generated Topic Pages">microbiota</a> research has shifted towards improving the understanding of the activity and functionality of <a href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/intestine-flora" title="Learn more about gut microbiota from ScienceDirect's AI-generated Topic Pages">gut microbiota</a> rather than <a href="https://www.sciencedirect.com/topics/chemistry/phase-composition" title="Learn more about composition from ScienceDirect's AI-generated Topic Pages">composition</a> alone. Currently, metabolomics plays an emerging role in precision nutrition and the recent developments therein are discussed.<br></p></div>