Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures : an exploratory study

Bekkering Siroon; Saner Christoph; Novakovic Boris; Mansell Toby; Longmore Danielle K.; McCallum Zoe; Ponsonby Anne-Louise; Juonala Markus; Netea Mihai G.; Sabin Matthew A.; Saffery Richard; Riksen Niels P.; Burgner David P.
Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures : an exploratory study

Bekkering Siroon
Saner Christoph
Novakovic Boris
Mansell Toby
Longmore Danielle K.
McCallum Zoe
Ponsonby Anne-Louise
Juonala Markus
Netea Mihai G.
Sabin Matthew A.
Saffery Richard
Riksen Niels P.
Burgner David P.
Katso/Avaa
Lataukset: 

Cell Press
doi:10.1016/j.isci.2024.109762
URI
https://doi.org/10.1016/j.isci.2024.109762
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2025082786073
Tiivistelmä

Cardiometabolic risk accrues across the lifecourse and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but paediatric data are scarce. In a cross-sectional and longitudinal study, we investigated immune cell composition and activation in 31 adolescents with obesity (41.9% male, BMIz>2.5, 14.4y) and 22 controls with healthy weight (45.1% male, -1.5

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