A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research

Yan Jiaqi; Ran Meixin; Zhang Hongbo
A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research

Yan Jiaqi
Ran Meixin
Zhang Hongbo
Katso/Avaa
Lataukset: 

Publishing services by Elsevier on behalf of KeAi Communications
doi:10.1016/j.bmt.2023.01.004
URI
https://doi.org/10.1016/j.bmt.2023.01.004
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2025082790210
Tiivistelmä
Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.
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