Developing an electrochemical sensor for the in vivo measurements of dopamine

Abstract

<p>Measurements inside the human body are complicated. Here, we provide a short introduction of the main requirements for the successful <em>in vivo</em> determination of dopamine concentrations, together with a discussion of how the type of the measurements, short-term <em>vs.</em> long-term and dynamic <em>vs.</em> basal measurements, affects what is expected from the sensor material. Next, we provide a step-by-step guide for characterising electrode performance and performing <em>in vivo</em> measurements with practical tips. Finally, we discuss the typical approaches for overcoming the challenges set by the environment.</p>