Acute exercise mobilizes CD8(+) cytotoxic T cells and NK cells in lymphoma patients

Abstract

<p><b>Background:</b> Studies have shown that acute exercise can mobilize several leukocyte subpopulations in healthy individuals. Our aim was to investigate whether a 10-min acute exercise has an effect on immune cell proportions in lymphoma patients.</p><p><b>Methods:</b> This study included seven lymphoma patients referred to curative oncologic therapy. Three had Hodgkin and four non-Hodgkin lymphoma, one was female, and their mean age was 51. Patients underwent a 10-min acute exercise on a bicycle ergometer at moderate exercise intensity. Whole blood samples were taken at rest, immediately after exercise, and 30 min after exercise. Leukocyte subpopulation levels were determined using flow cytometry.</p><p><b>Results:</b> Proportions of total NK cells and CD56(+)CD16(+) NK cells of total leukocytes increased immediately after exercise and decreased back to baseline at 30 min post-exercise. Proportion of CD8(+) T cells of total T cells increased and proportion of CD4(+) T cells of total T cells decreased immediately after exercise, and both returned to baseline at 30 min post-exercise. There was no change in the proportions of B cells, granulocytes, or monocytes. Exercising diastolic blood pressure correlated positively with changes in total NK cell and CD56(+)CD16(+) NK cell proportions, and exercising mean arterial pressure correlated positively with change in CD56(+)CD16(+) NK cell proportion.</p><p><b>Conclusion:</b> Our findings indicate that a single acute exercise bout of only 10 min can cause leukocytosis in lymphoma patients, particularly on cytotoxic T cells and NK cells, which are the most important immune cells fighting against cancer.</p>