Transcatheter or Surgical Aortic Valve Replacement in patients with Severe Aortic Stenosis Aged 70 Years or Younger - a NOTION-2 sub-study

Jørgensen, Troels Højsgaard; Thyregod; Hans Gustav Hørsted; Savontaus, Mikko; Bleie, Öjvind; Christiansen, Evald H; Niemelä, Matti; Angerås, Oskar; Gudmundsdóttir, Ingibjörg J.; Laine, Mika; Rück, Andreas; Prendergast, Bernard; Leon, Martin; Søndergaard, Lars; De Backer, Ole; NOTION-2 investigators
Transcatheter or Surgical Aortic Valve Replacement in patients with Severe Aortic Stenosis Aged 70 Years or Younger - a NOTION-2 sub-study

Jørgensen, Troels Højsgaard
Thyregod
Hans Gustav Hørsted
Savontaus, Mikko
Bleie, Öjvind
Christiansen, Evald H
Niemelä, Matti
Angerås, Oskar
Gudmundsdóttir, Ingibjörg J.
Laine, Mika
Rück, Andreas
Prendergast, Bernard
Leon, Martin
Søndergaard, Lars
De Backer, Ole
NOTION-2 investigators
Katso/Avaa
Lataukset: 

Elsevier BV
doi:10.1016/j.ahj.2025.02.003
URI
https://doi.org/10.1016/j.ahj.2025.02.003
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2025082792421
Tiivistelmä

This NOTION-2 sub-study revealed distinct outcomes for transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in low surgical risk patients aged ≤ 70 years with a tricuspid or bicuspid aortic valve stenosis (AS). One year after intervention, the risk of death, stroke or rehospitalization in patients with tricuspid AS was similar after TAVR when compared to SAVR (absolute risk difference: -2.0%; 95% confidence interval (CI): -11.8% to 7.7%) Conversely, in patients with bicuspid AS, TAVR was associated with a significantly higher risk of adverse outcomes (absolute risk difference: 13.8%; 95% CI: 1.2% to 26.3%). These analyses are exploratory, but highlight the importance of tailoring the intervention to the patient's clinical risk profile, life expectancy, native aortic valve morphology and the anticipated risks associated with TAVR or SAVR.

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