LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation

Kalim, Ubaid Ullah; Shetty, Ankitha; Ranade, Amogh; Rundquist, Olof; Starskaia, Inna; Batkulwar, Kedar; Välikangas, Tommi; Sousa, António G. G.; Hurme, Antti; Kumpulainen, Venla; Viitala, Miro; Kosola, Sakari; Junttila, Sini; Rasool, Omid; Elo, Laura L.; Galande, Sanjeev; Lahesmaa, Riitta
LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation

Kalim, Ubaid Ullah
Shetty, Ankitha
Ranade, Amogh
Rundquist, Olof
Starskaia, Inna
Batkulwar, Kedar
Välikangas, Tommi
Sousa, António G. G.
Hurme, Antti
Kumpulainen, Venla
Viitala, Miro
Kosola, Sakari
Junttila, Sini
Rasool, Omid
Elo, Laura L.
Galande, Sanjeev
Lahesmaa, Riitta
Katso/Avaa
Lataukset: 

Cell Press
doi:10.1016/j.isci.2025.113779
URI
https://doi.org/10.1016/j.isci.2025.113779
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe202601216035
Tiivistelmä
Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and function. Here, we identified a lincRNA, LINC01871, which is highly induced upon CD4+ T cell activation and is predominantly located in the cytoplasm. The anti-inflammatory cytokine TGF-β was found to suppress its expression. Silencing LINC01871 led to a modest decrease in IL-2 secretion. Notably, LINC01871 expression was highly specific to NK cells and T cells in several cross-tissue single cell RNA-seq atlases. These data suggest that LINC01871 is specifically expressed in T and NK cells and may contribute to T cell-mediated immunity in humans.
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