Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments

Sousa‐Pinto, Bernardo; Bousquet, Jean; Vieira, Rafael José; Schünemann, Holger J.; Zuberbier, Torsten; Bognanni, Antonio; Togias, Alkis; Samolinski, Boleslaw; Valiulis, Arunas; Williams, Sian; Bedbrook, Anna; Czarlewski, Wienczyslawa; Torres, Maria Jose; Shamji, Mohamed H.; Morais‐Almeida, Mário; Canonica, G. Walter; de las Vecillas; Leticia; Dykewicz, Mark S.; Jacomelli, Cristina; Klimek, Ludger; Leemann, Lucas; Lourenço, Olga; Palamarchuk, Yuliia; Papadopoulos, Nikolaos G.; Pereira, Ana Margarida; Savouré, Marine; Toppila‐Salmi, Sanna K.; Ventura, Maria Teresa; Yepes‐Nuñez, Juan José; Cruz, Alvaro A.; Ciprandi, Giorgio; Gemicioglu, Bilun; Giovannini, Mattia; Gradauskiene, Brigita; Jartti, Tuomas; Jeseňák, Miloš; Kuna, Piotr; Kvedariene, Violeta; Larenas‐Linnemann, Désirée E.; Latiff, Amir H. A.; Mohammad, Yousser; Ohta, Ken; Mahesh, Padukudru A.; Pali‐Schöll, Isabella; Pfaar, Oliver; Regateiro, Frederico S.; Roche, Nicolas; Taborda‐Barata, Luís; Ulrik, Charlotte Suppli; Rostan, Marylin Valentin; Viegi, Giovanni; Zhang, Luo; Haahtela, Tari; Cherrez‐Ojeda, Ivan; Ivancevich, Juan Carlos; Khaltaev, Nikolai; Yorgancioglu, Arzu; Abdullah, Baharudin; Al‐Ahmad, Mona; Al‐Nesf, Maryam Ali; Amaral, Rita; Asllani, Julijana; Bergmann, Karl‐C.; Bernstein, Jonathan A.; Blaiss, Michael S.; Braido, Fulvio; Camargos, Paulo; Carreiro‐Martins, Pedro; Casale, Thomas; Cecchi, Lorenzo; Fiocchi, Alessandro; Giuliano, Antonio F. M.; Christoff, George; Cirule, Ieva; de Sousa; Jaime Correia; Costa, Elisio M.; Del Giacco, Stefano; Devillier, Philippe; Dokic, Dejan; Hossny, Elham; Iinuma, Tomohisa; Irani, Carla; Ispayeva, Zhanat; Julge, Kaja; Kaidashev, Igor; Bennoor, Kazi S.; Kraxner, Helga; Kull, Inger; Kulus, Marek; Kupczyk, Maciej; Kurchenko, Andriy; La Grutta, Stefania; Miculinic, Neven; Tuyet; Lan Le Thi; Makris, Michael; Milenkovic, Branislava; Lee, Sang Min; Montefort, Stephen; Moreira, Andre; Mullol, Joaquim; Nadif, Rachel; Nakonechna, Alla; Neffen, Hugo E.; Niedoszytko, Marek; Nyembue, Dieudonné; O'Hehir, Robyn E.; Ogulur, Ismail; Okamoto, Yoshitaka; Olze, Heidi; Palomares, Oscar; Panzner, Petr; Patella, Vincenzo; Pawankar, Ruby; Pitsios, Constantinos; Popov, Todor A.; Puggioni, Francesca; Quirce, Santiago; Ramonaité, Agné; Recto, Marysia; Repka‐Ramirez, Maria Susana; Roberts, Graham; Robles‐Velasco, Karla; Rottem, Menachem; Salapatas, Marianella; Sastre, Joaquin; Scichilone, Nicola; Sisul, Juan‐Carlos; Solé, Dirceu; Soto‐Martinez, Manuel E.; Sova, Milan; Tantilipikorn, Pongsakorn; Todo‐Bom, Ana; Tsaryk, Vladyslav; Tsiligianni, Ioanna; Urrutia‐Pereira, Marilyn; Valovirta, Erkka; Vasankari, Tuula; Wallace, Dana; Wang, De Yun; Worm, Margitta; Yusuf, Osman M.; Zidarn, Mihaela; Gil‐Mata, Sara; Marques‐Cruz, Manuel; Mahboub, Bassam; Ansotegui, Ignacio J.; Romano, Antonino; Aberer, Werner; Artesani, Maria Cristina; Azzolini, Elena; Barreto, Bruno; Bartra, Joan; Becker, Sven; Beghe, Bianca; Boner, Attilio; Borowiack, Ewa; Bouchard, Jacques; Bourgoin‐Heck, Melisande; Brussino, Luisa; Buhl, Roland; Castillo‐Vizuete, José Antonio; Charpin, Denis; Chavannes, Niels H.; Chełmińska, Marta; Cheng, Lei; Chkhartishvili, Ekaterine; Cho, Seong H.; Chong‐Neto, Herberto Jose; Choudhury, Deepa; Chu, Derek K.; Cingi, Cemal; Compalati, Enrico; Albuquerque Costa, Raquel; Cunha, Olga Mariana; Cvetkovski, Biljana; Cardona‐Dahl, Victoria; D'Amato, Gennaro; Davies, Janet; Di Bona, Danilo; Gonzalez, Diaz Sandra N.; Dimou, Maria V.; Doulaptsi, Maria; Ferreira‐da‐Silva, Renato; Gawlik, Radoslaw; Calvo‐Gil, Mario; Goksel, Ozlem; Gómez, Maximiliano R.; Gotua, Maia; Grigoreas, Christos; Grisle, Ineta; Guzman, Maria Antonieta; House Tan, Rachel; Hyland, Michael; Ierodiakonou, Despo; Karavelia, Aspasia; Keith, Paul; Kisiel, Marta; Kosak, Tanja Soklic; Kosnik, Mitja; Koyuncu, Ilgim Vardaloglu; Kritikos, Vicky; Litynska, Justyna; Lombardi, Carlo; Louis, Gilles; Martini, Matteo; Meço, Cem; Mesonjesi, Eris; Mihaltan, Florin; Moniuszko, Marcin; Naclerio, Robert N.; Nadeau, Kari C.; Neisinger, Sophia; Ollert, Markus; Ordak, Michal; Paoletti, Giovanni; Park, Hae‐Sim; Parmelli, Elena; Perdomo‐Flores, Edgar Arturo; Pérez; José Miguel Fuentes; Pham‐Thi, Nhan; Prokopakis, Emmanuel; Ribeiro‐Vaz, Inês; Rolla, Giovanni; Romantowski, Jan; Rombaux, Philippe; Rouadi, Philip W.; Rukhadze, Maia; Ryan, Dermot; Sadowska, Ewelina; Sakurai, Daiju; Salameh, Laila; Sarquis, Faradiba Serpa; Serrano, Elie; Da Silva, Jane; Soyka, Michael; Specjalski, Krzysztof; Tomic‐Spiric, Vesna; Stevanovic, Katarina; Subramaniam, Abirami; Do Ceu Teixeira; Maria; Thomander, Tuuli; Vachova, Martina; van Hage, Marianne; Vichyanond, Pakit; Wagenmann, Martin; Ko; Fanny Wai San; Werminghaus, Pascal; Xepapadaki, Paraskevi Vicky; Xiang, Yi‐Kui; Yang, Qintai; Yeverino, Daniela Rivero; Zuberbier, Jaron; Fonseca, João A.
Allergic Rhinitis and Its Impact on Asthma (ARIA)-EAACI Guidelines—2024–2025 Revision: Part I—Guidelines on Intranasal Treatments

Sousa‐Pinto, Bernardo
Bousquet, Jean
Vieira, Rafael José
Schünemann, Holger J.
Zuberbier, Torsten
Bognanni, Antonio
Togias, Alkis
Samolinski, Boleslaw
Valiulis, Arunas
Williams, Sian
Bedbrook, Anna
Czarlewski, Wienczyslawa
Torres, Maria Jose
Shamji, Mohamed H.
Morais‐Almeida, Mário
Canonica, G. Walter
de las Vecillas
Leticia
Dykewicz, Mark S.
Jacomelli, Cristina
Klimek, Ludger
Leemann, Lucas
Lourenço, Olga
Palamarchuk, Yuliia
Papadopoulos, Nikolaos G.
Pereira, Ana Margarida
Savouré, Marine
Toppila‐Salmi, Sanna K.
Ventura, Maria Teresa
Yepes‐Nuñez, Juan José
Cruz, Alvaro A.
Ciprandi, Giorgio
Gemicioglu, Bilun
Giovannini, Mattia
Gradauskiene, Brigita
Jartti, Tuomas
Jeseňák, Miloš
Kuna, Piotr
Kvedariene, Violeta
Larenas‐Linnemann, Désirée E.
Latiff, Amir H. A.
Mohammad, Yousser
Ohta, Ken
Mahesh, Padukudru A.
Pali‐Schöll, Isabella
Pfaar, Oliver
Regateiro, Frederico S.
Roche, Nicolas
Taborda‐Barata, Luís
Ulrik, Charlotte Suppli
Rostan, Marylin Valentin
Viegi, Giovanni
Zhang, Luo
Haahtela, Tari
Cherrez‐Ojeda, Ivan
Ivancevich, Juan Carlos
Khaltaev, Nikolai
Yorgancioglu, Arzu
Abdullah, Baharudin
Al‐Ahmad, Mona
Al‐Nesf, Maryam Ali
Amaral, Rita
Asllani, Julijana
Bergmann, Karl‐C.
Bernstein, Jonathan A.
Blaiss, Michael S.
Braido, Fulvio
Camargos, Paulo
Carreiro‐Martins, Pedro
Casale, Thomas
Cecchi, Lorenzo
Fiocchi, Alessandro
Giuliano, Antonio F. M.
Christoff, George
Cirule, Ieva
de Sousa
Jaime Correia
Costa, Elisio M.
Del Giacco, Stefano
Devillier, Philippe
Dokic, Dejan
Hossny, Elham
Iinuma, Tomohisa
Irani, Carla
Ispayeva, Zhanat
Julge, Kaja
Kaidashev, Igor
Bennoor, Kazi S.
Kraxner, Helga
Kull, Inger
Kulus, Marek
Kupczyk, Maciej
Kurchenko, Andriy
La Grutta, Stefania
Miculinic, Neven
Tuyet
Lan Le Thi
Makris, Michael
Milenkovic, Branislava
Lee, Sang Min
Montefort, Stephen
Moreira, Andre
Mullol, Joaquim
Nadif, Rachel
Nakonechna, Alla
Neffen, Hugo E.
Niedoszytko, Marek
Nyembue, Dieudonné
O'Hehir, Robyn E.
Ogulur, Ismail
Okamoto, Yoshitaka
Olze, Heidi
Palomares, Oscar
Panzner, Petr
Patella, Vincenzo
Pawankar, Ruby
Pitsios, Constantinos
Popov, Todor A.
Puggioni, Francesca
Quirce, Santiago
Ramonaité, Agné
Recto, Marysia
Repka‐Ramirez, Maria Susana
Roberts, Graham
Robles‐Velasco, Karla
Rottem, Menachem
Salapatas, Marianella
Sastre, Joaquin
Scichilone, Nicola
Sisul, Juan‐Carlos
Solé, Dirceu
Soto‐Martinez, Manuel E.
Sova, Milan
Tantilipikorn, Pongsakorn
Todo‐Bom, Ana
Tsaryk, Vladyslav
Tsiligianni, Ioanna
Urrutia‐Pereira, Marilyn
Valovirta, Erkka
Vasankari, Tuula
Wallace, Dana
Wang, De Yun
Worm, Margitta
Yusuf, Osman M.
Zidarn, Mihaela
Gil‐Mata, Sara
Marques‐Cruz, Manuel
Mahboub, Bassam
Ansotegui, Ignacio J.
Romano, Antonino
Aberer, Werner
Artesani, Maria Cristina
Azzolini, Elena
Barreto, Bruno
Bartra, Joan
Becker, Sven
Beghe, Bianca
Boner, Attilio
Borowiack, Ewa
Bouchard, Jacques
Bourgoin‐Heck, Melisande
Brussino, Luisa
Buhl, Roland
Castillo‐Vizuete, José Antonio
Charpin, Denis
Chavannes, Niels H.
Chełmińska, Marta
Cheng, Lei
Chkhartishvili, Ekaterine
Cho, Seong H.
Chong‐Neto, Herberto Jose
Choudhury, Deepa
Chu, Derek K.
Cingi, Cemal
Compalati, Enrico
Albuquerque Costa, Raquel
Cunha, Olga Mariana
Cvetkovski, Biljana
Cardona‐Dahl, Victoria
D'Amato, Gennaro
Davies, Janet
Di Bona, Danilo
Gonzalez, Diaz Sandra N.
Dimou, Maria V.
Doulaptsi, Maria
Ferreira‐da‐Silva, Renato
Gawlik, Radoslaw
Calvo‐Gil, Mario
Goksel, Ozlem
Gómez, Maximiliano R.
Gotua, Maia
Grigoreas, Christos
Grisle, Ineta
Guzman, Maria Antonieta
House Tan, Rachel
Hyland, Michael
Ierodiakonou, Despo
Karavelia, Aspasia
Keith, Paul
Kisiel, Marta
Kosak, Tanja Soklic
Kosnik, Mitja
Koyuncu, Ilgim Vardaloglu
Kritikos, Vicky
Litynska, Justyna
Lombardi, Carlo
Louis, Gilles
Martini, Matteo
Meço, Cem
Mesonjesi, Eris
Mihaltan, Florin
Moniuszko, Marcin
Naclerio, Robert N.
Nadeau, Kari C.
Neisinger, Sophia
Ollert, Markus
Ordak, Michal
Paoletti, Giovanni
Park, Hae‐Sim
Parmelli, Elena
Perdomo‐Flores, Edgar Arturo
Pérez
José Miguel Fuentes
Pham‐Thi, Nhan
Prokopakis, Emmanuel
Ribeiro‐Vaz, Inês
Rolla, Giovanni
Romantowski, Jan
Rombaux, Philippe
Rouadi, Philip W.
Rukhadze, Maia
Ryan, Dermot
Sadowska, Ewelina
Sakurai, Daiju
Salameh, Laila
Sarquis, Faradiba Serpa
Serrano, Elie
Da Silva, Jane
Soyka, Michael
Specjalski, Krzysztof
Tomic‐Spiric, Vesna
Stevanovic, Katarina
Subramaniam, Abirami
Do Ceu Teixeira
Maria
Thomander, Tuuli
Vachova, Martina
van Hage, Marianne
Vichyanond, Pakit
Wagenmann, Martin
Ko
Fanny Wai San
Werminghaus, Pascal
Xepapadaki, Paraskevi Vicky
Xiang, Yi‐Kui
Yang, Qintai
Yeverino, Daniela Rivero
Zuberbier, Jaron
Fonseca, João A.
Katso/Avaa
Lataukset: 

Wiley
doi:10.1111/all.70131
URI
https://doi.org/10.1111/all.70131
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe202601217156
Tiivistelmä

Background

Allergic rhinitis (AR) impacts quality of life, work and school productivity. Over the last years, an important body of evidence resulting from mHealth data has led to a better understanding of AR. Such advances have motivated an EAACI-endorsed update of the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines (ARIA 2024–2025). This manuscript presents the ARIA 2024–2025 recommendations for intranasal treatments, one of the mainstays for AR management.

Methods

The ARIA 2024–2025 guideline panel issued recommendations following the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) evidence-to-decision framework. Several sources of evidence were used to inform panel judgments and recommendations, including systematic reviews, evaluation of mHealth and pharmacovigilance data, as well as a survey of experts on costs.

Results

Eleven guideline questions concerning intranasal treatments for AR were prioritized, leading to recommendations. Overall, these questions concern the choice between different classes of intranasal medications—most notably, intranasal corticosteroids (INCS), antihistamines (INAH), fixed combinations of INAH+INCS and decongestants—or between different individual medications within each class. Four questions had not been evaluated in previous ARIA guidelines, while for the other three there was a change in the strength or directionality of recommendations. Overall, recommendations point to the suggested use of INAH+INCS over INAH or INCS and INCS over INAH.

Conclusion

This ARIA 2024–2025 article supports patients, their caregivers, and healthcare professionals in choosing an intranasal treatment. However, decisions on AR treatment should consider the clinical variability of the disease, patients' values, and the affordability of medications.

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