Impact of the COVID-19 pandemic on the quality of life of early breast cancer patients undergoing adjuvant chemotherapy – an observational, multicenter study

Abstract

<p><b>Background and purpose</b><br></p><p>We evaluated the impact of the coronavirus disease 2019 (COVID-19) pan-demic on health-related quality of life (HRQoL) in early-stage breast cancer patients receiving adjuvant chemotherapy.<br></p><p><b>Patients and methods</b><br></p><p>The study involved 180 patients with stage I–III breast cancer who initiated adju-vant chemotherapy between June 2020 and May 2021. The pre-pandemic comparison data included 113 early breast cancer patients who began adjuvant chemotherapy between November 2018 and August 2019. HRQoL was assessed using the EORTC QLQ-C30 at baseline and again after 3 and 6 months. The sub-scales were compared between the COVID-19 pandemic and the pre-pandemic eras.<br></p><p><b>Results</b><br></p><p>We observed deterioration on almost all HRQoL subscales of the patients treated during the pan-demic from baseline to 3 months. After the chemotherapy at 6 months, the scales remained deteriorated, whereas only appetite loss and emotional functioning improved. A comparison between the pandemic and the pre-pandemic eras revealed that several HRQoL subscales showed better results during chemo-therapy in the pandemic era. Global health and role functioning at 6 months presented declined levels during the pandemic.<br></p><p><b>Interpretation</b><br></p><p>The well-being of breast cancer patients during the chemotherapy treatment in the pandemic era was moderately better than in the pre-pandemic era. Patients in the pandemic era might have reported fewer symptoms during the treatment, as the focus was on the COVID-19 pandemic and its restrictions.<br></p>