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Aineistot 1-10 / 15
Comparison of five popular normalization methods using a spike-in proteomics data set
(Turun yliopisto, 2016-08-18)
Mass spectrometry (MS)-based proteomics has seen significant technical advances during the past two decades and mass spectrometry has become a central tool in many biosciences. Despite the popularity of MS-based methods, ...
Probing MST1 Kinase Sequence and Structure for Rational Drug Discovery (Targeting diabetes by blocking protein-protein interactions)
(Turun yliopisto, 2016-04-26)
Apoptotic beta cell death is an underlying cause majorly for type I and to a lesser extent for type II diabetes. Recently, MST1 kinase was identified as a key apoptotic agent in diabetic condition. In this study, I have ...
Human Ezrin: Prediction of the 3D structure and interactions with mTOR
(Turun yliopisto, 2016-06-15)
The protein Ezrin, is a member of the ERM family (Ezrin, Radixin and Moesin) that links the F-actin to the plasma membrane. The protein is made of three domains namely the FERM domain, a central α-helical domain and the ...
Phylogenetic Analysis of Avidins and Expression of Novel Avidins from Lactrodectus hesperus and Hoeflea phototrophica
(Turun yliopisto, 2015-11-05)
Avidins (Avds) are homotetrameric or homodimeric glycoproteins with typically less than 130 amino acid residues per monomer. They form a highly stable, non-covalent complex with biotin (vitamin H) with Kd = 10-15 M (for ...
Adopting the Vaadin Java framework to rebuild VTT’s Web Interfaces and Database Applications
(Turun yliopisto, 2015-12-14)
With the growth in new technologies, using online tools have become an everyday lifestyle. It has a greater impact on researchers as the data obtained from various experiments needs to be analyzed and knowledge of programming ...
Structural and Mechanistic Studies of Phosphoserine Aminotransferase
(Turun yliopisto, 2015-12-11)
Phosphoserine aminotrasferase (PSAT: EC 2.6.1.52) is a vitamin B6-dependent enzyme and a member of the subgroup IV in the aminotransferase superfamily. Here, X-ray crystallography was used to determine the structure of ...
Optimization and Applications of Large-Scale Biomedical Event Networks
(Turun yliopisto, 2016-06-01)
The overwhelming amount and unprecedented speed of publication in the biomedical domain make it difficult for life science researchers to acquire and maintain a broad view of the field and gather all information that would ...
Analysis of Alpha CA Genes in Early Vertebrates and ; High-Invertebrates
(Turun yliopisto, 2016-06-08)
Carbonic anhydrases are enzymes that are ubiquitously found in all organisms that are engaged in catalyzing the hydration of carbon dioxide to form bicarbonate and proton and vice versa. They are crucial in the process of ...
Implementation of Quantitative Reaction-based Model Refinement
(Turun yliopisto, 2015-10-13)
Building a computational model for complex biological systems is an iterative process. It starts from an abstraction of the process and then incorporates more details regarding the specific biochemical reactions which ...
Prediction of Phosphorylation Sites from Protein Sequences
(Turun yliopisto, 2016-06-15)
Phosphorylation is amongst the most crucial and well-studied post-translational modifications. It is involved in multiple cellular processes which makes phosphorylation prediction vital for understanding protein functions. ...