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Ex vivo characterization of joint innervating neurons in osteoarthritic rodent pain model
(2023-08-28)
Osteoarthritis (OA) is the most common joint disease worldwide, affecting an estimate of 240 million people. The predominant symptom of OA is pain. Pain perception arises from nociceptive signals in the periphery, that ...
Resurgence of pertussis and strategies of B. pertussis to evade acellular vaccine induced immunity
(2024-03-08)
In countries where acellular pertussis (aP) vaccines are used, there has been a rise in B. pertussis isolates that do not produce certain vaccine antigens, such as pertactin (PRN). In Finland, the whole-cell pertussis (wP) ...
Unihäiriöiden merkitys Alzheimerin taudissa
(2024-06-03)
Aivoja rappeuttava Alzheimerin tauti on yksi yleisimmistä dementian aiheuttajista, ja sen yleisyys lisääntyy ikääntyessä. Alzheimerin tauti on monimutkainen ja etenevä hermorappeumasairaus, jonka oireita ovat tiedonkäsit ...
The role of melanocortin 1 receptor in physiological cardiac hypertrophy in mice
(2024-04-15)
Melanocortin 1 receptor (MC1R) is known from its expression in the skin and regulation of skin and hair pigmentation. Recently, it has found to be expressed also in the heart, but its functional role has remained unknown. ...
NRG1/ERBB Axis in Drug Tolerance to Targeted Cancer Therapies
(2024-04-29)
Targeted therapies have benefited many patients, but resistance significantly hinders the long-term efficacy of these treatments. Development of resistance is complex and can occur through various mechanisms including ...
Whole-genome sequencing in a Finnish high-risk prostate cancer family to identify a novel cancer predisposition gene
(2024-05-02)
The etiology of prostate cancer (PCa) is significantly associated with hereditary genetic predisposition.
However, a large portion of PCa with hereditary predisposition lacks the knowledge of the causative
genetic ...
CHARACTERIZATION OF NOVEL FACTORS REGULATING ENDOTHELIAL BARRIER DURING METASTASIS
(2024-04-11)
Progressive, metastatic cancer is a leading cause of cancer-related deaths worldwide. One of the critical
steps of the metastatic cascade is the colonization of circulating tumor cells in the distant tissues, where ...
Interactions and activity of lysergol derivatives at 5 HT1A and 5-HT2A–C receptors
(2024-04-16)
Traditional use of psychedelics has historically remained restricted between religious ceremonies and countercultural movements. With the pathophysiology of various neuropsychiatric disorders becoming clearer, the world ...
Screening Optimal Vaccine Adjuvants for Recombinant Protein-Based Coronavirus Vaccine
(2024-05-08)
To fully prevent respiratory diseases like COVID-19, vaccines need to activate mucosal immune responses. Yet, all current COVID-19 vaccines are administered intramuscularly, which, while effective at generating high levels ...
The effect of bexmarilimab on acute myeloid leukemia cells
(2024-05-06)
Acute myeloid leukemia (AML) is a hematological disease, caused by uncontrollable differentiation of immature hematopoietic cells. AML is treated with intensive chemotherapy or with targeted treatments, but despite the ...