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Comparison of DNA damage biomarker dynamics after induced DNA damage : Study of DNA damage biomarker expression and dynamics in cancer cells
(2022-05-02)
To ensure genomic integrity and protect cells from a variety of DNA damaging agents, cells have developed a complex network called the DNA damage response (DDR). It monitors and ensures DNA integrity by coordinating DNA ...
The iron-entry pores in Dps-like proteins as a potential drug-design targe: Structural investigations
(2022-06-01)
Streptococcus suis is an emerging catalase-negative zoonotic pathogen that uses the peroxide resistance protein (Dpr) as a defensive mechanism against oxidative stress. Dpr belongs to a family of proteins that form spherical ...
Contribution of BIM Serine 87 phosphorylation on targeted therapy response
(2022-06-06)
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are the standard-of-care for the treatment of EGFR-mutant non-small cell lung cancer (NSCLC) with typically excellent response rates. However, no ...
Retinal plasticity in the context of a partially rescued retinitis pigmentosa mouse model
(2022-03-28)
Retinitis pigmentosa (RP) is a major cause of hereditary blindness and visual disability. The prevalence of RP is estimated to be 1/4000, affecting approximately 2.5 million people worldwide. RP is a very slow-progressing ...
Role of Glucose Transporters in osteoblastic cells
(2022-01-31)
Human skeleton is undergoing a constant remodeling through coupled actions of bone resorbing osteoclasts and bone forming osteoblasts and this remodeling process requires a constant source of energy for the cells. Different ...
Discovery of RAR-related Orphan Receptor γt Inverse Agonists
(2021-11-30)
BACKGROUND
Technological advances have provided modern approaches for drug discovery and development. Its application, computer-aided drug design (CADD), enables solving complex drug design challenges practically unsolvable ...
Microbiota-derived extracellular vesicles cargo composition analysis using hTLR cell lines
(2022-03-28)
Bacterial cells interact with other bacteria and their host cells via direct interaction or the secretion of soluble components, such bacterial extracellular vesicles (BEVs). BEVs distribute a portion of the parent bacterium ...
SHANK-regulation of drug sensitivity in KRAS-driven cancer
(2022-05-02)
Ras proteins are intracellular GTPase switch proteins activating MAPK/ERK signaling pathways in their active GTP-bound forms. Mutant KRAS oncoproteins are mostly in their active state, fostering ERK-dependent cell proliferation ...
Optimisation of adeno-associated viral vector production using Design of Experiments
(2022-04-29)
Adeno-associated virus (AAV) vectors are widely used in in vivo gene therapy. The increasing popularity leads to demand for higher manufacturing capacities. The yield achieved with the most common production method, triple ...
Specific immunoglobulin E analysis in adults presenting with birch pollen allergy symptoms
(2022-04-27)
The increase of IgE-mediated allergies and asthma is a socioeconomic challenge in developed countries. Although there are millions of people suffering from different types of allergies, they are often underdiagnosed, and ...