Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

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dc.contributor.authorYaiw, Koon Chu
dc.contributor.authorFerrer, Isidre A.
dc.contributor.authorSöderberg-Nauclér, Cecilia
dc.contributor.authorReliga, Dorota
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organizationfi=MediCity|en=MediCity|
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id515530097
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/515530097
dc.date.accessioned2026-04-24T16:28:17Z
dc.description.abstractHuman cytomegalovirus (HCMV), a ubiquitous DNA betaherpesvirus, is capable of persistent infection and immunomodulation, particularly in immunocompromised and elderly hosts. Emerging evidence links HCMV to neurodegenerative diseases through its multifaceted immunomodulatory effects. This review summarizes key viral architectures and mechanisms, epidemiological trends, and experimental data supporting HCMV's role in cognitive decline. We advocate for targeted antiviral strategies and vaccine development to clarify its contribution to neurodegeneration.
dc.identifier.eissn1663-4365
dc.identifier.urihttps://www.utupub.fi/handle/11111/58711
dc.identifier.urlhttps://doi.org/10.3389/fnagi.2025.1757461
dc.identifier.urnURN:NBN:fi-fe2026022315462
dc.language.isoen
dc.okm.affiliatedauthorNaucler, Cecilia
dc.okm.affiliatedauthorDataimport, MediCity
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherFrontiers Media SA
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumber1757461
dc.relation.doi10.3389/fnagi.2025.1757461
dc.relation.ispartofjournalFrontiers in Aging Neuroscience
dc.relation.volume17
dc.titleHuman cytomegalovirus infection and cognitive decline: insights from population and experimental studies
dc.year.issued2026

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