Homeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance

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dc.contributor.authorCrisóstomo, Luís
dc.contributor.authorParena, Ae
dc.contributor.authorHyseni, Besmir
dc.contributor.authorBergman, Hans
dc.contributor.authorMildner, Alexander
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=MediCity|en=MediCity|
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.contributor.organization-code1.2.246.10.2458963.20.83772236069
dc.contributor.organization-code2607051
dc.converis.publication-id459082354
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/459082354
dc.date.accessioned2025-08-27T20:48:15Z
dc.date.available2025-08-27T20:48:15Z
dc.description.abstractTissue-resident macrophages are best known for their indispensable role in immunological reactions, where they contribute to immune defense and resolution of inflammation. However, recent studies have also uncovered that they provide crucial tissue-specific functions that support organ homeostasis and maintenance. Accordingly, defects in macrophage function or development can disrupt the delicate balance of organ homeostasis, leading to pathological conditions. Therefore, understanding the functions and development of macrophages within a tissue is critical for comprehending the interplay between immune and stromal cells, which together maintain organ physiology. This knowledge has clinical implications, such as in organ transplantation or irradiation, where monocyte-derived cells with different functions may replace the original macrophage population. In this chapter, we aim to provide an overview of the tissue-specific homeostatic functions of various macrophage populations, emphasizing that macrophages are essential components of each organ and play a vital role in ensuring the organism's survival, beyond their role in immunity.
dc.format.pagerange3
dc.format.pagerange54
dc.identifier.eisbn978-3-031-65944-7
dc.identifier.isbn978-3-031-65943-0
dc.identifier.issn0080-1844
dc.identifier.olddbid200260
dc.identifier.oldhandle10024/183287
dc.identifier.urihttps://www.utupub.fi/handle/11111/45950
dc.identifier.urlhttps://doi.org/10.1007/978-3-031-65944-7_1
dc.identifier.urnURN:NBN:fi-fe2025081883263
dc.language.isoen
dc.okm.affiliatedauthorMachado Crisóstomo, Luís
dc.okm.affiliatedauthorParena, Aeron Jade
dc.okm.affiliatedauthorMäkinen, Aeron Jade
dc.okm.affiliatedauthorHyseni, Besmir
dc.okm.affiliatedauthorBergman, Hans
dc.okm.affiliatedauthorMildner, Alexander
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeB2 Book
dc.publisherSpringer
dc.publisher.countryGermanyen_GB
dc.publisher.countrySaksafi_FI
dc.publisher.country-codeDE
dc.publisher.isbn978-81-322;978-3-540;978-3-642;978-3-662;978-3-7908;978-3-8274;978-3-8347;978-90-481;978-94-007;978-94-009;978-94-010;978-94-011;978-94-015;978-94-017;978-94-024;978-0-387;978-0-8176;978-1-4419;978-1-4612;978-1-4613;978-1-4614;978-1-4615;978-1-4684;978-1-4757;978-1-4899;978-1-4939;978-1-5041;978-3-319;978-1-4020;978-0-85729;978-1-4471;978-1-84628;978-1-84800;978-1-84882;978-1-84996;978-1-85233;978-3-211;978-3-7091;978-4-431;978-3-322;978-3-409;978-3-531;978-3-658;978-3-663;978-3-8100;978-981-287;978-981-10;978-981-13;978-3-030;978-981-32;978-981-15;978-981-16;978-981-329;978-981-334;978-981-336;978-3-031;978-981-19;
dc.relation.doi10.1007/978-3-031-65944-7_1
dc.relation.ispartofseriesResults and Problems in Cell Differentiation
dc.relation.volume74
dc.source.identifierhttps://www.utupub.fi/handle/10024/183287
dc.titleHomeostatic Functions of Tissue-Resident Macrophages and Their Role in Tissue Maintenance
dc.title.bookMonocytes and Macrophages in Development, Regeneration, and Disease
dc.year.issued2024

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