Synthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules

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dc.contributor.authorGulumkar Vijay
dc.contributor.authorTähtinen Ville
dc.contributor.authorAli Aliaa
dc.contributor.authorRahkila Jani
dc.contributor.authorValle-Delgado Juan José
dc.contributor.authorÄärelä Antti
dc.contributor.authorÖsterberg Monika
dc.contributor.authorYliperttula Marjo
dc.contributor.authorVirta Pasi
dc.contributor.organizationfi=lääkekehityksen kemia|en=Pharmaseutical Chemistry|
dc.contributor.organization-code1.2.246.10.2458963.20.93793350823
dc.contributor.organization-code2606303
dc.converis.publication-id175000519
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/175000519
dc.date.accessioned2022-10-28T13:15:39Z
dc.date.available2022-10-28T13:15:39Z
dc.description.abstract<p>Bingel cyclopropanation between Buckminster fullerene and a heteroarmed malonate was utilized to produce a hexakis-functionalized C<sub>60</sub> core, with azide and tetrazine units. This orthogonally bifunctional C<sub>60</sub> scaffold can be selectively one-pot functionalized by two pericyclic click reactions, that is, inverse electron-demand Diels-Alder and azide-alkyne cycloaddition, which with appropriate ligands (monosaccharides, a peptide and oligonucleotides tested) allows one to control the assembly of heteroantennary bioconjugates.<br></p>
dc.format.pagerange1329
dc.format.pagerange1336
dc.identifier.eissn2470-1343
dc.identifier.jour-issn2470-1343
dc.identifier.olddbid180876
dc.identifier.oldhandle10024/163970
dc.identifier.urihttps://www.utupub.fi/handle/11111/36390
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acsomega.1c05955
dc.identifier.urnURN:NBN:fi-fe2022081154520
dc.language.isoen
dc.okm.affiliatedauthorGulumkar, Vijay
dc.okm.affiliatedauthorTähtinen, Ville
dc.okm.affiliatedauthorÄärelä, Antti
dc.okm.affiliatedauthorVirta, Pasi
dc.okm.discipline116 Chemical sciencesen_GB
dc.okm.discipline116 Kemiafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherAMER CHEMICAL SOC
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1021/acsomega.1c05955
dc.relation.ispartofjournalACS Omega
dc.relation.issue1
dc.relation.volume7
dc.source.identifierhttps://www.utupub.fi/handle/10024/163970
dc.titleSynthesis of an Azide- and Tetrazine-Functionalized [60]Fullerene and Its Controlled Decoration with Biomolecules
dc.year.issued2022

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