Large scale statistically validated comorbidity networks

Abstract

<p>We obtain comorbidity networks starting from medical information stored in electronic health records collected by the Wellbeing Services County of Southwest Finland (Varha). Based on the data, we connect each patient to one or more diseases and construct complex comorbidity networks associated with large patient cohorts characterized by an age interval and sex. The information about diseases in electronic health records is coded using the highest granularity present in the international classification of diseases (ICD codes) provided by the World Health Organization. We statistically validate links in each cohort's comorbidity network and furthermore partition the networks into communities of diseases. These are characterized by the over-expression of a few disease categories, and communities from different age or sex cohorts show various similarities in terms of these disease classes. Moreover, the detected communities for all the cohorts can be organized into a hierarchical tree. This allows us to observe a number of clusters of communities - originating from diverse age and sex cohorts - that group together communities characterized by the same disease classes. We also perform a dismantling procedure of statistically validated comorbidity networks to highlight those categories of diseases that are most responsible for the compactedness of the comorbidity networks for a given cohort of patients.<br></p>