Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Tietueen suppeat tiedot
dc.contributor.authorMia Ståhle
dc.contributor.authorJohanna M.U. Silvola
dc.contributor.authorSanna Hellberg
dc.contributor.authorMargreet de Vries
dc.contributor.authorPaul H. A. Quax
dc.contributor.authorJeffrey Kroon
dc.contributor.authorPetteri Rinne
dc.contributor.authorAlwin de Jong
dc.contributor.authorHeidi Liljenbäck
dc.contributor.authorNina Savisto
dc.contributor.authorAnna Wickman
dc.contributor.authorErik S.G. Stroes
dc.contributor.authorSeppo Ylä-Herttuala
dc.contributor.authorPekka Saukko
dc.contributor.authorTommy Abrahamsson
dc.contributor.authorKnut Pettersson
dc.contributor.authorJuhani Knuuti
dc.contributor.authorAnne Roivainen
dc.contributor.authorAntti Saraste
dc.contributor.author
dc.contributor.organizationfi=PET-keskus|en=Turku PET Centre|
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organizationfi=sisätautioppi|en=Internal Medicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.14646305228
dc.contributor.organization-code1.2.246.10.2458963.20.40502528769
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.contributor.organization-code2609810
dc.contributor.organization-code2609830
dc.converis.publication-id47290852
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/47290852
dc.date.accessioned2022-10-27T12:25:24Z
dc.date.available2022-10-27T12:25:24Z
dc.description.abstract<p>This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.<br /></p>
dc.format.pagerange360
dc.format.pagerange373
dc.identifier.eissn2452-302X
dc.identifier.jour-issn2452-302X
dc.identifier.olddbid175411
dc.identifier.oldhandle10024/158505
dc.identifier.urihttps://www.utupub.fi/handle/11111/29774
dc.identifier.urnURN:NBN:fi-fe2021042823708
dc.language.isoen
dc.okm.affiliatedauthorStåhle, Mia
dc.okm.affiliatedauthorSilvola, Johanna
dc.okm.affiliatedauthorHellberg, Sanna
dc.okm.affiliatedauthorRinne, Petteri
dc.okm.affiliatedauthorLiljenbäck, Heidi
dc.okm.affiliatedauthorSarja, Nina
dc.okm.affiliatedauthorSaukko, Pekka
dc.okm.affiliatedauthorKnuuti, Juhani
dc.okm.affiliatedauthorRoivainen, Anne
dc.okm.affiliatedauthorSaraste, Antti
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherElsevier Inc
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.doi10.1016/j.jacbts.2020.01.008
dc.relation.ispartofjournalJACC: Basic to Translational Science
dc.relation.issue4
dc.relation.volume5
dc.source.identifierhttps://www.utupub.fi/handle/10024/158505
dc.titleTherapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice
dc.year.issued2020

Tiedostot

Näytetään 1 - 1 / 1
Name:
1-s2.0-S2452302X20300206-main.pdf
Size:
4.11 MB
Format:
Adobe Portable Document Format
Description:
Publisher's version
Lataa

Kokoelmat

Rinnakkaistallenteet