Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

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dc.contributor.authorKilpeläinen T.O.
dc.contributor.authorBentley A.R.
dc.contributor.authorNoordam R.
dc.contributor.authorSung Y.J.
dc.contributor.authorSchwander K.
dc.contributor.authorWinkler T.W.
dc.contributor.authorJakupović H.
dc.contributor.authorChasman D.I.
dc.contributor.authorManning A.
dc.contributor.authorNtalla I.
dc.contributor.authorAschard H.
dc.contributor.authorBrown M.R.
dc.contributor.authorde las Fuentes L.
dc.contributor.authorFranceschini N.
dc.contributor.authorGuo X.
dc.contributor.authorVojinovic D.
dc.contributor.authorAslibekyan S.
dc.contributor.authorFeitosa M.F.
dc.contributor.authorKho M.
dc.contributor.authorMusani S.K.
dc.contributor.authorRichard M.
dc.contributor.authorWang H.
dc.contributor.authorWang Z.
dc.contributor.authorBartz T.M.
dc.contributor.authorBielak L.F.
dc.contributor.authorCampbell A.
dc.contributor.authorDorajoo R.
dc.contributor.authorFisher V.
dc.contributor.authorHartwig F.P.
dc.contributor.authorHorimoto A.R.V.R.
dc.contributor.authorLi C.
dc.contributor.authorLohman K.K.
dc.contributor.authorMarten J.
dc.contributor.authorSim X.
dc.contributor.authorSmith A.V.
dc.contributor.authorTajuddin S.M.
dc.contributor.authorAlver M.
dc.contributor.authorAmini M.
dc.contributor.authorBoissel M.
dc.contributor.authorChai J.F.
dc.contributor.authorChen X.
dc.contributor.authorDivers J.
dc.contributor.authorEvangelou E.
dc.contributor.authorGao C.
dc.contributor.authorGraff M.
dc.contributor.authorHarris S.E.
dc.contributor.authorHe M.
dc.contributor.authorHsu F.-C.
dc.contributor.authorJackson A.U.
dc.contributor.authorZhao J.H.
dc.contributor.authorKraja A.T.
dc.contributor.authorKühnel B.
dc.contributor.authorLaguzzi F.
dc.contributor.authorLyytikäinen L.-P.
dc.contributor.authorNolte I.M.
dc.contributor.authorRauramaa R.
dc.contributor.authorRiaz M.
dc.contributor.authorRobino A.
dc.contributor.authorRueedi R.
dc.contributor.authorStringham H.M.
dc.contributor.authorTakeuchi F.
dc.contributor.authorvan der Most P.J.
dc.contributor.authorVarga T.V.
dc.contributor.authorVerweij N.
dc.contributor.authorWare E.B.
dc.contributor.authorWen W.
dc.contributor.authorLi X.
dc.contributor.authorYanek L.R.
dc.contributor.authorAmin N.
dc.contributor.authorArnett D.K.
dc.contributor.authorBoerwinkle E.
dc.contributor.authorBrumat M.
dc.contributor.authorCade B.
dc.contributor.authorCanouil M.
dc.contributor.authorChen Y.-D.I.
dc.contributor.authorConcas M.P.
dc.contributor.authorConnell J.
dc.contributor.authorde Mutsert R.
dc.contributor.authorde Silva H.J.
dc.contributor.authorde Vries P.S.
dc.contributor.authorDemirkan A.
dc.contributor.authorDing J.
dc.contributor.authorEaton C.B.
dc.contributor.authorFaul J.D.
dc.contributor.authorFriedlander Y.
dc.contributor.authorGabriel K.P.
dc.contributor.authorGhanbari M.
dc.contributor.authorGiulianini F.
dc.contributor.authorGu C.C.
dc.contributor.authorGu D.
dc.contributor.authorHarris T.B.
dc.contributor.authorHe J.
dc.contributor.authorHeikkinen S.
dc.contributor.authorHeng C.-K.
dc.contributor.authorHunt S.C.
dc.contributor.authorIkram M.A.
dc.contributor.authorJonas J.B.
dc.contributor.authorKoh W.-P.
dc.contributor.authorKomulainen P.
dc.contributor.authorKrieger J.E.
dc.contributor.authorKritchevsky S.B.
dc.contributor.authorKutalik Z.
dc.contributor.authorKuusisto J.
dc.contributor.authorLangefeld C.D.
dc.contributor.authorLangenberg C.
dc.contributor.authorLauner L.J.
dc.contributor.authorLeander K.
dc.contributor.authorLemaitre R.N.
dc.contributor.authorLewis C.E.
dc.contributor.authorLiang J.
dc.contributor.authorAlizadeh B.Z.
dc.contributor.authorBoezen H.M.
dc.contributor.authorFranke L.
dc.contributor.authorNavis G.
dc.contributor.authorRots M.
dc.contributor.authorSwertz M.
dc.contributor.authorWolffenbuttel B.H.R.
dc.contributor.authorWijmenga C.
dc.contributor.authorLiu J.
dc.contributor.authorMägi R.
dc.contributor.authorManichaikul A.
dc.contributor.authorMeitinger T.
dc.contributor.authorMetspalu A.
dc.contributor.authorMilaneschi Y.
dc.contributor.authorMohlke K.L.
dc.contributor.authorMosley T.H.
dc.contributor.authorJr.
dc.contributor.authorMurray A.D.
dc.contributor.authorNalls M.A.
dc.contributor.authorNang E.-E.K.
dc.contributor.authorNelson C.P.
dc.contributor.authorNona S.
dc.contributor.authorNorris J.M.
dc.contributor.authorNwuba C.V.
dc.contributor.authorO’Connell J.
dc.contributor.authorPalmer N.D.
dc.contributor.authorPapanicolau G.J.
dc.contributor.authorPazoki R.
dc.contributor.authorPedersen N.L.
dc.contributor.authorPeters A.
dc.contributor.authorPeyser P.A.
dc.contributor.authorPolasek O.
dc.contributor.authorPorteous D.J.
dc.contributor.authorPoveda A.
dc.contributor.authorRaitakari O.T.
dc.contributor.authorRich S.S.
dc.contributor.authorRisch N.
dc.contributor.authorRobinson J.G.
dc.contributor.authorRose L.M.
dc.contributor.authorRudan I.
dc.contributor.authorSchreiner P.J.
dc.contributor.authorScott R.A.
dc.contributor.authorSidney S.S.
dc.contributor.authorSims M.
dc.contributor.authorSmith J.A.
dc.contributor.authorSnieder H.
dc.contributor.authorSofer T.
dc.contributor.authorStarr J.M.
dc.contributor.authorSternfeld B.
dc.contributor.authorStrauch K.
dc.contributor.authorTang H.
dc.contributor.authorTaylor K.D.
dc.contributor.authorTsai M.Y.
dc.contributor.authorTuomilehto J.
dc.contributor.authorUitterlinden A.G.
dc.contributor.authorvan der Ende M.Y.
dc.contributor.authorvan Heemst D.
dc.contributor.authorVoortman T.
dc.contributor.authorWaldenberger M.
dc.contributor.authorWennberg P.
dc.contributor.authorWilson G.
dc.contributor.authorXiang Y.-B.
dc.contributor.authorYao J.
dc.contributor.authorYu C.
dc.contributor.authorYuan J.-M.
dc.contributor.authorZhao W.
dc.contributor.authorZonderman A.B.
dc.contributor.authorBecker D.M.
dc.contributor.authorBoehnke M.
dc.contributor.authorBowden D.W.
dc.contributor.authorde Faire U.
dc.contributor.authorDeary I.J.
dc.contributor.authorElliott P.
dc.contributor.authorEsko T.
dc.contributor.authorFreedman B.I.
dc.contributor.authorFroguel P.
dc.contributor.authorGasparini P.
dc.contributor.authorGieger C.
dc.contributor.authorKato N.
dc.contributor.authorLaakso M.
dc.contributor.authorLakka T.A.
dc.contributor.authorLehtimäki T.
dc.contributor.authorMagnusson P.K.E.
dc.contributor.authorOldehinkel A.J.
dc.contributor.authorPenninx B.W.J.H.
dc.contributor.authorSamani N.J.
dc.contributor.authorShu X.-O.
dc.contributor.authorvan der Harst P.
dc.contributor.authorVan Vliet-Ostaptchouk J.V.
dc.contributor.authorVollenweider P.
dc.contributor.authorWagenknecht L.E.
dc.contributor.authorWang Y.X.
dc.contributor.authorWareham N.J.
dc.contributor.authorWeir D.R.
dc.contributor.authorWu T.
dc.contributor.authorZheng W.
dc.contributor.authorZhu X.
dc.contributor.authorEvans M.K.
dc.contributor.authorFranks P.W.
dc.contributor.authorGudnason V.
dc.contributor.authorHayward C.
dc.contributor.authorHorta B.L.
dc.contributor.authorKelly T.N.
dc.contributor.authorLiu Y.
dc.contributor.authorNorth K.E.
dc.contributor.authorPereira A.C.
dc.contributor.authorRidker P.M.
dc.contributor.authorTai E.S.
dc.contributor.authorvan Dam R.M.
dc.contributor.authorFox E.R.
dc.contributor.authorKardia S.L.R.
dc.contributor.authorLiu C.-T.
dc.contributor.authorMook-Kanamori D.O.
dc.contributor.authorProvince M.A.
dc.contributor.authorRedline S.
dc.contributor.authorvan Duijn C.M.
dc.contributor.authorRotter J.I.
dc.contributor.authorKooperberg C.B.
dc.contributor.authorGauderman W.J.
dc.contributor.authorPsaty B.M.
dc.contributor.authorRice K.
dc.contributor.authorMunroe P.B.
dc.contributor.authorFornage M.
dc.contributor.authorCupples L.A.
dc.contributor.authorRotimi C.N.
dc.contributor.authorMorrison A.C.
dc.contributor.authorRao D.C.
dc.contributor.authorLoos R.J.F.
dc.contributor.authorLifelines Cohort Study
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.35734063924
dc.converis.publication-id39425566
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/39425566
dc.date.accessioned2022-10-27T12:20:40Z
dc.date.available2022-10-27T12:20:40Z
dc.description.abstractMany genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol- increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
dc.identifier.jour-issn2041-1723
dc.identifier.olddbid174859
dc.identifier.oldhandle10024/157953
dc.identifier.urihttps://www.utupub.fi/handle/11111/35036
dc.identifier.urlhttps://www.nature.com/articles/s41467-018-08008-w
dc.identifier.urnURN:NBN:fi-fe2021042823265
dc.language.isoen
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline1184 Genetics, developmental biology, physiologyen_GB
dc.okm.discipline1184 Genetiikka, kehitysbiologia, fysiologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherNATURE PUBLISHING GROUP
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.articlenumberARTN 376
dc.relation.doi10.1038/s41467-018-08008-w
dc.relation.ispartofjournalNature Communications
dc.relation.volume10
dc.source.identifierhttps://www.utupub.fi/handle/10024/157953
dc.titleMulti-ancestry study of blood lipid levels identifies four loci interacting with physical activity
dc.year.issued2019

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