Cognitive Effects of White Matter Pathology in Normal and Pathological Aging

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dc.contributor.authorKaskikallio A.
dc.contributor.authorKarrasch M.
dc.contributor.authorRinne J.O.
dc.contributor.authorTuokkola T.
dc.contributor.authorParkkola R.
dc.contributor.authorGrönholm-Nyman P.
dc.contributor.organizationfi=PET-keskus|en=Turku PET Centre|
dc.contributor.organizationfi=kliininen fysiologia ja isotooppilääketiede|en=Clinical Physiology and Isotope Medicine|
dc.contributor.organizationfi=kliininen laitos|en=Department of Clinical Medicine|
dc.contributor.organizationfi=kuvantaminen ja kliininen diagnostiikka|en=Imaging and Clinical Diagnostics|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.61334543354
dc.contributor.organization-code1.2.246.10.2458963.20.69079168212
dc.contributor.organization-code2607322
dc.converis.publication-id39535018
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/39535018
dc.date.accessioned2022-10-28T13:03:15Z
dc.date.available2022-10-28T13:03:15Z
dc.description.abstractWe examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer's disease (total n = 149), controlling for age and education. Trend-level effects of white matter pathology on cognition were only observed in patients with Alzheimer's disease (p = 0.062, eta(2) = 0.052), patients with severe frontal white matter pathology performed notably worse than those with milder pathology. This indicates that frontal cerebrovascular pathology may have an additive negative effect on cognition in Alzheimer's disease.
dc.format.pagerange489
dc.format.pagerange493
dc.identifier.jour-issn1387-2877
dc.identifier.olddbid179377
dc.identifier.oldhandle10024/162471
dc.identifier.urihttps://www.utupub.fi/handle/11111/37088
dc.identifier.urlhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad180554
dc.identifier.urnURN:NBN:fi-fe2021042820947
dc.language.isoen
dc.okm.affiliatedauthorRinne, Juha
dc.okm.affiliatedauthorTuokkola, Terhi
dc.okm.affiliatedauthorParkkola, Riitta
dc.okm.affiliatedauthorDataimport, 2609820 PET Tutkimus
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3124 Neurology and psychiatryen_GB
dc.okm.discipline3124 Neurologia ja psykiatriafi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherIOS PRESS
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.doi10.3233/JAD-180554
dc.relation.ispartofjournalJournal of Alzheimer's Disease
dc.relation.issue2
dc.relation.volume67
dc.source.identifierhttps://www.utupub.fi/handle/10024/162471
dc.titleCognitive Effects of White Matter Pathology in Normal and Pathological Aging
dc.year.issued2019

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