Bioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats

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dc.contributor.authorLinderborg Kaisa M.
dc.contributor.authorKulkarni Amruta
dc.contributor.authorZhao Ai
dc.contributor.authorZhang Jian
dc.contributor.authorKallio Heikki
dc.contributor.authorMagnusson Johann D.
dc.contributor.authorHaraldsson Gudmundur G.
dc.contributor.authorZhang Yumei
dc.contributor.authorYang Baoru
dc.contributor.organizationfi=elintarviketieteet|en=Food Sciences|
dc.contributor.organization-code1.2.246.10.2458963.20.15178954341
dc.contributor.organization-code2610103
dc.converis.publication-id39151018
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/39151018
dc.date.accessioned2022-10-28T14:05:02Z
dc.date.available2022-10-28T14:05:02Z
dc.description.abstractLack of synthetic enantiospecific triacylglycerols (TAGs) has hindered our understanding of the impact of TAG structure on the absorption and metabolic fate of fatty acids (FAs). In a five-day feeding trial with mildly (n-3) deficient rats, the bioavailability of docosahexaenoic acid [22:6(n-3), DHA] and stearic acid (18:0) from the two different enantiomers of TAG: sn-22:6(n-3)-18:0-18:0 and sn-18:0-18:0-22:6(n-3), and their regioisomeric TAG: sn-18:0-22:6(n-3)-18:0 was compared. Less secretion of fecal DHA was detected from the sn-2 position compared with the sn-1 and sn-3 positions, but no difference was found in DHA content of the fasting plasma or in the weight of the body or organs. 18:0 was lost to feces mainly as cleaved from the primary positions but also as glycerol-bound. The 5-day intervention in rats was long enough to modify the fatty acid profile of plasma phospholipids.
dc.format.pagerange381
dc.format.pagerange389
dc.identifier.eissn1873-7072
dc.identifier.jour-issn0308-8146
dc.identifier.olddbid186163
dc.identifier.oldhandle10024/169257
dc.identifier.urihttps://www.utupub.fi/handle/11111/31917
dc.identifier.urnURN:NBN:fi-fe2021042825008
dc.language.isoen
dc.okm.affiliatedauthorLinderborg, Kaisa
dc.okm.affiliatedauthorKallio, Heikki
dc.okm.affiliatedauthorYang, Baoru
dc.okm.affiliatedauthorKulkarni, Amruta
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1016/j.foodchem.2018.12.130
dc.relation.ispartofjournalFood Chemistry
dc.relation.volume283
dc.source.identifierhttps://www.utupub.fi/handle/10024/169257
dc.titleBioavailability of docosahexaenoic acid 22:6(n-3) from enantiopure triacylglycerols and their regioisomeric counterpart in rats
dc.year.issued2019

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