Scanning transmission soft X-ray spectromicroscopy of mouse kidney and liver

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dc.contributor.authorMansikkala Tuomas
dc.contributor.authorOhigashi Takuji
dc.contributor.authorSalo Miia H.
dc.contributor.authorHiltunen Anniina E.
dc.contributor.authorVuolteenaho Reetta
dc.contributor.authorSipilä Petra
dc.contributor.authorKuure Satu
dc.contributor.authorHuttula Marko
dc.contributor.authorUusimaa Johanna
dc.contributor.authorHinttala Reetta
dc.contributor.authorMiinalainen Ilkka
dc.contributor.authorKangas Salla
dc.contributor.authorPatanen Minna
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id180472953
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/180472953
dc.date.accessioned2025-08-28T02:03:34Z
dc.date.available2025-08-28T02:03:34Z
dc.description.abstract<p>Scanning transmission X-ray microscopy (STXM) in the soft X-ray range is well-suited to study ultrastructural features of mammalian soft tissues. Especially at the carbon 1s edge, the imaging contrast varies drastically across the edge due to rapid changes in the X-ray absorption cross-section of functional groups present in the tissue samples enabling label-free soft X-ray spectromicroscopic studies. We present STXM spectromicroscopic imaging of mouse kidney and liver tissues. We especially concentrate on ultrastructural abnormalities in genetically modified Slc17a5 mice. STXM is a promising technique to study storage diseases without chemical alteration due to staining agents, but sample preparation poses a challenge.<br></p>
dc.identifier.eissn1873-2526
dc.identifier.jour-issn0368-2048
dc.identifier.olddbid208517
dc.identifier.oldhandle10024/191544
dc.identifier.urihttps://www.utupub.fi/handle/11111/57951
dc.identifier.urlhttps://doi.org/10.1016/j.elspec.2023.147368
dc.identifier.urnURN:NBN:fi-fe2025082792020
dc.language.isoen
dc.okm.affiliatedauthorSipilä, Petra
dc.okm.discipline3126 Surgery, anesthesiology, intensive care, radiologyen_GB
dc.okm.discipline3126 Kirurgia, anestesiologia, tehohoito, radiologiafi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherElsevier B.V.
dc.publisher.countryNetherlandsen_GB
dc.publisher.countryAlankomaatfi_FI
dc.publisher.country-codeNL
dc.relation.articlenumber147368
dc.relation.doi10.1016/j.elspec.2023.147368
dc.relation.ispartofjournalJournal of Electron Spectroscopy and Related Phenomena
dc.relation.volume266
dc.source.identifierhttps://www.utupub.fi/handle/10024/191544
dc.titleScanning transmission soft X-ray spectromicroscopy of mouse kidney and liver
dc.year.issued2023

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