PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity

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dc.contributor.authorKhan Mohd Moin
dc.contributor.authorKalim Ubaid Ullah
dc.contributor.authorKhan Meraj H
dc.contributor.authorLahesmaa Riitta
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.converis.publication-id174926668
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/174926668
dc.date.accessioned2022-10-28T13:19:54Z
dc.date.available2022-10-28T13:19:54Z
dc.description.abstractProtein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.
dc.identifier.eissn1664-3224
dc.identifier.olddbid181331
dc.identifier.oldhandle10024/164425
dc.identifier.urihttps://www.utupub.fi/handle/11111/41848
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2021.786857
dc.identifier.urnURN:NBN:fi-fe2022081154405
dc.language.isoen
dc.okm.affiliatedauthorKhan, Mohd
dc.okm.affiliatedauthorKalim, Ubaid Ullah
dc.okm.affiliatedauthorKhan, Meraj
dc.okm.affiliatedauthorLahesmaa, Riitta
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA2 Scientific Article
dc.publisherFRONTIERS MEDIA SA
dc.publisher.countrySwitzerlanden_GB
dc.publisher.countrySveitsifi_FI
dc.publisher.country-codeCH
dc.relation.articlenumber786857
dc.relation.doi10.3389/fimmu.2021.786857
dc.relation.ispartofjournalFrontiers in immunology
dc.relation.volume12
dc.source.identifierhttps://www.utupub.fi/handle/10024/164425
dc.titlePP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
dc.year.issued2022

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