Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma

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dc.contributor.authorRoutila Erica
dc.contributor.authorMahran Randa
dc.contributor.authorSalminen Seppo
dc.contributor.authorIrjala Heikki
dc.contributor.authorHaapio Eeva
dc.contributor.authorKytö E
dc.contributor.authorVentelä Sami
dc.contributor.authorPetterson Kim
dc.contributor.authorRoutila Johannes
dc.contributor.authorGidwani Kamlesh
dc.contributor.authorLeivo Janne
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organizationfi=biotekniikka|en=Biotechnology|
dc.contributor.organizationfi=korva-, nenä-, ja kurkkutautioppi|en=Otorhinolaryngology - Head and Neck Surgery|
dc.contributor.organizationfi=lääkekehityksen kemia|en=Pharmaseutical Chemistry|
dc.contributor.organizationfi=ravitsemus- ja ruokatutkimuskeskus|en=Nutrition and Food Research Center (NuFo)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.12007811941
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.contributor.organization-code1.2.246.10.2458963.20.93326749889
dc.contributor.organization-code1.2.246.10.2458963.20.98373201676
dc.contributor.organization-code2606303
dc.contributor.organization-code2607051
dc.contributor.organization-code2607312
dc.converis.publication-id387645817
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/387645817
dc.date.accessioned2025-08-27T12:55:31Z
dc.date.available2025-08-27T12:55:31Z
dc.description.abstract<p><b>Background:</b> Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.</p><p><b>Methods:</b> Tumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens were performed.</p><p><b>Results:</b> Strong correlation between glycosylation profiles of all four stemness-related proteins was observed in tumor tissue, whereas glycosylation in tumor tissue, adjacent normal tissue, and serum was differential.</p><p><b>Conclusions:</b> A mannose- and galactose-rich glycosylation niche associated with stemness-related proteins was identified.</p>
dc.identifier.eissn1471-2407
dc.identifier.jour-issn1471-2407
dc.identifier.olddbid199877
dc.identifier.oldhandle10024/182904
dc.identifier.urihttps://www.utupub.fi/handle/11111/44616
dc.identifier.urlhttps://bmccancer.biomedcentral.com/articles/10.1186/s12885-024-12161-5
dc.identifier.urnURN:NBN:fi-fe2025082788882
dc.language.isoen
dc.okm.affiliatedauthorRoutila, Erica
dc.okm.affiliatedauthorMahran, Randa
dc.okm.affiliatedauthorSalminen, Seppo
dc.okm.affiliatedauthorIrjala, Heikki
dc.okm.affiliatedauthorHaapio, Eeva
dc.okm.affiliatedauthorKytö, Eero
dc.okm.affiliatedauthorVentelä, Sami
dc.okm.affiliatedauthorPettersson, Kim
dc.okm.affiliatedauthorRoutila, Johannes
dc.okm.affiliatedauthorGidwani, Kamlesh
dc.okm.affiliatedauthorLeivo, Janne
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3122 Cancersen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.discipline3122 Syöpätauditfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherBioMed Central
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.articlenumber443
dc.relation.doi10.1186/s12885-024-12161-5
dc.relation.ispartofjournalBMC Cancer
dc.relation.volume24
dc.source.identifierhttps://www.utupub.fi/handle/10024/182904
dc.titleIdentification of stemness-related glycosylation changes in head and neck squamous cell carcinoma
dc.year.issued2024

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