Chlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019

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dc.contributor.authorKaisu Rantakokko-Jalava
dc.contributor.authorKati Hokynar
dc.contributor.authorNiina Hieta
dc.contributor.authorAnniina Keskitalo
dc.contributor.authorPia Jokela
dc.contributor.authorAnna Muotiala
dc.contributor.authorT. Sakari Jokiranta
dc.contributor.authorRutta Kuusela
dc.contributor.authorHannu Sarkkinen
dc.contributor.authorJanne Aittoniemi
dc.contributor.authorTytti Vuorinen
dc.contributor.authorAntti J. Hakanen
dc.contributor.authorMirja Puolakkainen
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organizationfi=iho- ja sukupuolitautioppi|en=Dermatology and Venereology|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.39855016430
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.contributor.organization-code2607100
dc.converis.publication-id41233824
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/41233824
dc.date.accessioned2022-10-28T12:40:51Z
dc.date.available2022-10-28T12:40:51Z
dc.description.abstractSince February 2019, over 160 Chlamydia trachomatis (CT) cases testing negative or equivocal by Aptima Combo 2 (AC2) but positive by Aptima CT test run with Panther instruments occurred in Finland. The AC2 test targets chlamydial 23S rRNA while the CT test targets 16S rRNA. Sequencing of 10 strains revealed a nucleotide substitution in 23S rRNA. The significance of this for the failure of the AC2 test to detect the variant is not yet known.
dc.format.pagerange2
dc.format.pagerange5
dc.identifier.jour-issn1025-496X
dc.identifier.olddbid178182
dc.identifier.oldhandle10024/161276
dc.identifier.urihttps://www.utupub.fi/handle/11111/50414
dc.identifier.urnURN:NBN:fi-fe2021042825804
dc.language.isoen
dc.okm.affiliatedauthorRantakokko-Jalava, Kaisu
dc.okm.affiliatedauthorHieta, Niina
dc.okm.affiliatedauthorKeskitalo, Anniina
dc.okm.affiliatedauthorVuorinen, Tytti
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorHakanen, Antti
dc.okm.discipline1182 Biochemistry, cell and molecular biologyen_GB
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline1182 Biokemia, solu- ja molekyylibiologiafi_FI
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationnot an international co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherEUR CENTRE DIS PREVENTION & CONTROL
dc.publisher.countrySwedenen_GB
dc.publisher.countryRuotsifi_FI
dc.publisher.country-codeSE
dc.relation.articlenumberARTN 1900298
dc.relation.doi10.2807/1560-7917.ES.2019.24.22.1900298
dc.relation.ispartofjournalEurosurveillance
dc.relation.issue22
dc.relation.volume24
dc.source.identifierhttps://www.utupub.fi/handle/10024/161276
dc.titleChlamydia trachomatis samples testing falsely negative in the Aptima Combo 2 test in Finland, 2019
dc.year.issued2019

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