Stroma AReactive invasion Front Areas (SARIFA) in early-stage oral tongue squamous cell carcinoma

Abstract

<h3>Background</h3><p>Stroma AReactive Invasion Front Areas (SARIFA) has recently been introduced as a prognostic indicator. The prognostic value of SARIFA has not been studied in early-stage oral tongue squamous cell carcinoma (OTSCC).</p><h3>Material and methods</h3><p>A total of 287 cases of early-stage OTSCC were included in this multicenter study. SARIFA was defined as direct contact between tumor cells and the adipose tissue, and was assessed in hematoxylin and eosin (HE)-stained sections.</p><h3>Results</h3><p>In early-stage OTSCC, SARIFA-positive tumors were associated with worse disease-specific survival with a hazard ratio (HR) of 1.86 (95% CI 1.06–3.28, <em>P</em> = 0.032), overall survival (HR 1.52, 95% CI 1.06–2.19, <em>P</em> = 0.023) and disease-free survival (HR 1.79, 95% CI 1.09–2.93, <em>P</em> = 0.021).</p><h3>Conclusions</h3><p>SARIFA is a histomorphology-based prognosticator, that can identify cases with early-stage OTSCC who might benefit from a multimodality treatment protocol.</p>