Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

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dc.contributor.authorMucci L.
dc.contributor.authorWest C.
dc.contributor.authorKoutros S.
dc.contributor.authorCancel-Tassin G.
dc.contributor.authorMaehle L.
dc.contributor.authorSorensen K.
dc.contributor.authorTravis R.
dc.contributor.authorNeal D.
dc.contributor.authorBatra J.
dc.contributor.authorTangen C.
dc.contributor.authorGronberg H.
dc.contributor.authorClements J.
dc.contributor.authorAlbanes D.
dc.contributor.authorSchleutker J.
dc.contributor.authorWolk A.
dc.contributor.authorWeinstein S.
dc.contributor.authorPenney K.
dc.contributor.authorPark J.
dc.contributor.authorStanford J.
dc.contributor.authorCybulski C.
dc.contributor.authorNordestgaard B.
dc.contributor.authorBrenner H.
dc.contributor.authorMaier C.
dc.contributor.authorKim J.
dc.contributor.authorHamilton R.
dc.contributor.authorIngles S.
dc.contributor.authorRosenstein B.
dc.contributor.authorLu Y.
dc.contributor.authorGiles G.
dc.contributor.authorKibel A.
dc.contributor.authorVega A.
dc.contributor.authorKogevinas M.
dc.contributor.authorDominguez M.
dc.contributor.authorTownsend P.
dc.contributor.authorClaessens F.
dc.contributor.authorUsmani N.
dc.contributor.authorMenegaux F.
dc.contributor.authorRoobol M.
dc.contributor.authorDe Ruyck K.
dc.contributor.authorNeuhausen S.
dc.contributor.authorTeixeira M.
dc.contributor.authorJohn E.
dc.contributor.authorKaneva R.
dc.contributor.authorLessel D.
dc.contributor.authorNewcomb L.
dc.contributor.authorRazack A.
dc.contributor.authorVijayakrishnan J.
dc.contributor.authorKumar R.
dc.contributor.authorLaw P.
dc.contributor.authorHarrison C.
dc.contributor.authorAllan J.
dc.contributor.authorBroderick P.
dc.contributor.authorStudd J.
dc.contributor.authorHolroyd A.
dc.contributor.authorKinnersley B.
dc.contributor.authorSheridan E.
dc.contributor.authorKinsey S.
dc.contributor.authorIrving J.
dc.contributor.authorThompson P.
dc.contributor.authorVora A.
dc.contributor.authorMoorman A.
dc.contributor.authorRachakonda S.
dc.contributor.authorRoman E.
dc.contributor.authorPharaoh P.
dc.contributor.authorDunning A.
dc.contributor.authorJöckel K.
dc.contributor.authorEaston D.
dc.contributor.authorNöthen M.
dc.contributor.authorHeilmann-Heimbach S.
dc.contributor.authorKoehler R.
dc.contributor.authorHoffmann P.
dc.contributor.authorPashayan N.
dc.contributor.authorGreaves M.
dc.contributor.authorKote-Jarai Z.
dc.contributor.authorMuir K.
dc.contributor.authorSwerdlow A.
dc.contributor.authorEeles R.
dc.contributor.authorPeto J.
dc.contributor.authorCanzian F.
dc.contributor.authorHaiman C.
dc.contributor.authorHenderson B.
dc.contributor.authorHoulston R.
dc.contributor.authorHemminki K.
dc.contributor.authorStanulla M.
dc.contributor.authorSchrappe M.
dc.contributor.authorBartram C.
dc.contributor.authorZimmerman M.
dc.contributor.authorStevens V.
dc.contributor.authorChanock S.
dc.contributor.authorWiklund F.
dc.contributor.authorConti D.
dc.contributor.authorBerndt S.
dc.contributor.authorOlama A.
dc.contributor.authorSchumacher F.
dc.contributor.authorBenlloch S.
dc.contributor.organizationfi=biolääketieteen laitos|en=Institute of Biomedicine|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, varha|
dc.contributor.organization-code1.2.246.10.2458963.20.77952289591
dc.converis.publication-id31531455
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/31531455
dc.date.accessioned2022-10-28T12:27:09Z
dc.date.available2022-10-28T12:27:09Z
dc.description.abstract<p>Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, <i>P</i> = 3.86 × 10<sup>−9</sup>, odds ratio (OR) = 1.34) and for <i>ETV6-RUNX1</i> fusion-positive BCP-ALL at 2q22.3 (rs17481869, <i>P</i> = 3.20 × 10<sup>−8</sup>, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.<br /></p>
dc.identifier.jour-issn2041-1723
dc.identifier.olddbid176495
dc.identifier.oldhandle10024/159589
dc.identifier.urihttps://www.utupub.fi/handle/11111/48097
dc.identifier.urnURN:NBN:fi-fe2021042719200
dc.language.isoen
dc.okm.affiliatedauthorSchleutker, Johanna
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherNature Publishing Group
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.articlenumber1340
dc.relation.doi10.1038/s41467-018-03178-z
dc.relation.ispartofjournalNature Communications
dc.relation.volume9
dc.source.identifierhttps://www.utupub.fi/handle/10024/159589
dc.titleGenome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
dc.year.issued2018

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