LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation

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dc.contributor.authorKalim, Ubaid Ullah
dc.contributor.authorShetty, Ankitha
dc.contributor.authorRanade, Amogh
dc.contributor.authorRundquist, Olof
dc.contributor.authorStarskaia, Inna
dc.contributor.authorBatkulwar, Kedar
dc.contributor.authorVälikangas, Tommi
dc.contributor.authorSousa, António G. G.
dc.contributor.authorHurme, Antti
dc.contributor.authorKumpulainen, Venla
dc.contributor.authorViitala, Miro
dc.contributor.authorKosola, Sakari
dc.contributor.authorJunttila, Sini
dc.contributor.authorRasool, Omid
dc.contributor.authorElo, Laura L.
dc.contributor.authorGalande, Sanjeev
dc.contributor.authorLahesmaa, Riitta
dc.contributor.organizationfi=InFLAMES Lippulaiva|en=InFLAMES Flagship|
dc.contributor.organizationfi=MediCity|en=MediCity|
dc.contributor.organizationfi=Turun biotiedekeskus|en=Turku Bioscience Centre|
dc.contributor.organization-code1.2.246.10.2458963.20.18586209670
dc.contributor.organization-code1.2.246.10.2458963.20.68445910604
dc.contributor.organization-code1.2.246.10.2458963.20.83772236069
dc.contributor.organization-code2609201
dc.converis.publication-id505586490
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/505586490
dc.date.accessioned2026-01-21T12:34:16Z
dc.date.available2026-01-21T12:34:16Z
dc.description.abstractLong intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. Recent findings highlight the importance of lincRNAs in regulating T cell development and function. Here, we identified a lincRNA, LINC01871, which is highly induced upon CD4+ T cell activation and is predominantly located in the cytoplasm. The anti-inflammatory cytokine TGF-β was found to suppress its expression. Silencing LINC01871 led to a modest decrease in IL-2 secretion. Notably, LINC01871 expression was highly specific to NK cells and T cells in several cross-tissue single cell RNA-seq atlases. These data suggest that LINC01871 is specifically expressed in T and NK cells and may contribute to T cell-mediated immunity in humans.
dc.identifier.eissn2589-0042
dc.identifier.olddbid212678
dc.identifier.oldhandle10024/195696
dc.identifier.urihttps://www.utupub.fi/handle/11111/52963
dc.identifier.urlhttps://doi.org/10.1016/j.isci.2025.113779
dc.identifier.urnURN:NBN:fi-fe202601216035
dc.language.isoen
dc.okm.affiliatedauthorKalim, Ubaid Ullah
dc.okm.affiliatedauthorShetty, Ankitha
dc.okm.affiliatedauthorRanade, Amogh
dc.okm.affiliatedauthorRundquist, Olof
dc.okm.affiliatedauthorStarskaia, Inna
dc.okm.affiliatedauthorBatkulwar, Kedar
dc.okm.affiliatedauthorVälikangas, Tommi
dc.okm.affiliatedauthorGoncalves de Sousa, Antonio
dc.okm.affiliatedauthorHurme, Antti
dc.okm.affiliatedauthorViitala, Miro
dc.okm.affiliatedauthorJunttila, Sini
dc.okm.affiliatedauthorRasool, Omid
dc.okm.affiliatedauthorElo, Laura
dc.okm.affiliatedauthorLahesmaa, Riitta
dc.okm.discipline3111 Biomedicineen_GB
dc.okm.discipline3111 Biolääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeA1 ScientificArticle
dc.publisherCell Press
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.articlenumber113779
dc.relation.doi10.1016/j.isci.2025.113779
dc.relation.ispartofjournaliScience
dc.relation.issue11
dc.relation.volume28
dc.source.identifierhttps://www.utupub.fi/handle/10024/195696
dc.titleLINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4+ T cell activation
dc.year.issued2025

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